Department of Pharmaceutics, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.
Department of Food and Drug Control, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.
Pharm Dev Technol. 2022 Mar;27(3):251-267. doi: 10.1080/10837450.2021.2021941. Epub 2022 May 11.
High porous particles with specific aerodynamic properties were processed by the spray freeze-drying (SFD) method. Comprehensive knowledge about all aspects of the SFD method is required for particle engineering of various pharmaceutical products with good flow properties. In this review, different types of the SFD method, the most frequently employed excipients, properties of particles prepared by this method, and most recent approaches concerning SFD are summarized. Generally, this technique can prepare spherical-shaped particles with a highly porous interior structure, responsible for the very low density of powders. Increasing the solubility of spray freeze-dried formulations achieves the desired efficacy. Also, due to the high efficiency of SFD, by determining the different features of this method and optimizing the process by model-based studies, desirable results for various inhaled products can be achieved and significant progress can be made in the field of pulmonary drug delivery.
采用喷雾冷冻干燥（SFD）方法制备具有特定空气动力学特性的高多孔颗粒。需要全面了解 SFD 方法的各个方面，才能对具有良好流动性的各种医药产品进行颗粒工程设计。在本综述中，总结了不同类型的 SFD 方法、最常使用的赋形剂、通过该方法制备的颗粒的性质以及与 SFD 相关的最新方法。通常，该技术可以制备具有高多孔内部结构的球形颗粒，这是粉末密度非常低的原因。提高喷雾冷冻干燥制剂的溶解度可达到预期的疗效。此外，由于 SFD 的高效率，通过确定该方法的不同特点并通过基于模型的研究优化工艺，可以为各种吸入产品获得理想的结果，并在肺部药物输送领域取得重大进展。
