Phillips P C, Dhawan V, Strother S C, Sidtis J J, Evans A C, Allen J C, Rottenberg D A
Ann Neurol. 1987 Jan;21(1):59-63. doi: 10.1002/ana.410210111.
Regional glucose metabolic rate constants and blood-to-brain transport of rubidium were estimated using positron emission tomography in an adolescent patient with a brain tumor, before and after chemotherapy with intravenous high-dose methotrexate. Widespread depression of cerebral glucose metabolism was apparent 24 hours after drug administration, which may reflect reduced glucose phosphorylation, and the influx rate constant for 82Rb was increased, indicating a drug-induced alteration in blood-brain barrier function. Associated changes in neuropsychological performance, electroencephalogram, and plasma amino acid concentration were identified in the absence of evidence of systemic methotrexate toxicity, suggesting primary methotrexate neurotoxicity.
在一名患有脑肿瘤的青少年患者中，使用正电子发射断层扫描技术，在静脉注射高剂量甲氨蝶呤化疗前后，估计了局部葡萄糖代谢率常数和铷的血脑转运情况。给药24小时后，脑葡萄糖代谢普遍降低，这可能反映了葡萄糖磷酸化减少，并且82Rb的流入速率常数增加，表明血脑屏障功能发生了药物诱导的改变。在没有全身甲氨蝶呤毒性证据的情况下，发现了神经心理表现、脑电图和血浆氨基酸浓度的相关变化，提示存在原发性甲氨蝶呤神经毒性。
