Shukla Dhananjay, Kalliath Jay, Dhawan Anuradha
Retina- Vitreous Service, Ratan Jyoti Netralaya, Gwalior, India.
Department of Ophthalmology, NMC Specialty Hospital, Abu Dhabi, United Arab Emirates.
Clin Ophthalmol. 2021 Dec 15;15:4681-4688. doi: 10.2147/OPTH.S284613. eCollection 2021.
Ocular tuberculosis (OTB) is a rare, extrapulmonary manifestation of systemic TB, which has been a global etiology of uveitis for centuries, though concentrated in the developing world. OTB remains difficult to diagnose clinically despite a plethora of conventional and modern investigations. Tubercular retinal vasculitis (TRV) is a common and specific presentation of OTB but is variably defined in the literature in terms of clinical profile and the investigations essential for diagnosis and treatment. Ironically, the need and duration of antitubercular treatment is uncertain for this manifestation of ocular TB. The rationale and utility for corticosteroids is similarly equivocal for TRV. This review attempts to tease out a commonsense approach from the best available evidence and consensus in the literature to suspect, investigate and diagnose TRV with reasonable certainty, and institute appropriate treatment with due ethnic and geographic considerations.
眼结核(OTB)是系统性结核病的一种罕见的肺外表现形式,几个世纪以来一直是葡萄膜炎的全球病因,不过主要集中在发展中世界。尽管有大量传统和现代检查手段,但OTB在临床上仍难以诊断。结核性视网膜血管炎(TRV)是OTB常见且具有特异性的表现,但在文献中,其临床特征以及诊断和治疗所需的检查方面的定义各不相同。具有讽刺意味的是,对于这种眼结核表现形式,抗结核治疗的必要性和疗程尚不确定。皮质类固醇对于TRV的基本原理和效用同样不明确。本综述试图从现有最佳证据和文献共识中梳理出一种合理的方法,以便有合理把握地怀疑、检查和诊断TRV,并在适当考虑种族和地理因素的情况下进行适当治疗。