Collier B D, Greenberg M, Tikofsky R S, Hellman R S
Clin Nucl Med. 1987 Mar;12(3):226-8. doi: 10.1097/00003072-198703000-00017.
A 50-year-old male underwent extensive left frontal lobe resection for a Grade II astrocytoma. Resection margins were free of tumor, and the patient suffered no significant postoperative neurologic deficits. One month later the patient was referred to radiation therapy for further evaluation and possible treatment. Unenhanced and enhanced transmission computed tomograms (CT) were interpreted as suspicious for recurrent tumor. However, using CT, which is essentially an anatomic technique, may not allow one to distinguish between surgical changes and the morbid anatomic findings of recurrent tumor. Because Tc-99m DTPA will cross the blood-brain barrier at sites of active intercranial disease, brain scintigraphy frequently is of value in distinguishing between recurrent tumor with an unstable blood-brain barrier and healed surgical changes with a stabilized blood-brain barrier. Therefore, clinicians requested that a Tc-99m DTPA brain scintigram be performed so as to distinguish between active disease and healed surgical changes.
一名50岁男性因二级星形细胞瘤接受了广泛的左额叶切除术。切除边缘无肿瘤，患者术后无明显神经功能缺损。一个月后，患者被转诊接受放射治疗以进行进一步评估和可能的治疗。未增强和增强的透射计算机断层扫描（CT）显示为复发性肿瘤可疑。然而，使用本质上是一种解剖技术的CT可能无法区分手术改变和复发性肿瘤的病态解剖学表现。由于锝-99m二乙三胺五醋酸（Tc-99m DTPA）会在活跃的颅内疾病部位穿过血脑屏障，脑闪烁扫描在区分血脑屏障不稳定的复发性肿瘤和血脑屏障稳定的愈合手术改变方面通常具有价值。因此，临床医生要求进行Tc-99m DTPA脑闪烁扫描，以区分活跃疾病和愈合的手术改变。
