Campbell E A, Linton E A, Wolfe C D, Scraggs P R, Jones M T, Lowry P J
J Clin Endocrinol Metab. 1987 May;64(5):1054-9. doi: 10.1210/jcem-64-5-1054.
Plasma CRH was measured in maternal plasma throughout the third trimester of pregnancy, during labor, and postpartum. CRH levels were also measured in arterial and venous umbilical cord plasma samples. In normal pregnant women, plasma CRH increased from 50 +/- 15 (+/- SEM) pg/mL at 28 weeks gestation (n = 41) to 1462 +/- 182 pg/mL at 40 weeks (n = 55) and 1680 +/- 101 pg/mL (n = 65) in labor. Women with pregnancy-induced hypertension (n = 49) had plasma CRH levels significantly elevated above this normal range. Similarly, women who subsequently went into premature labor had raised levels several weeks before the onset of labor. After delivery, plasma CRH returned to normal within 15 h. Total plasma cortisol levels varied little throughout the third trimester, but increased during labor and remained elevated 2-3 days postpartum. There was, therefore, no correlation between plasma cortisol and CRH, implying that this placental CRH is not primarily involved in the control of the maternal hypothalamo-pituitary adrenal axis during pregnancy. The concentrations of CRH in umbilical cord plasma samples were considerably lower than those in the maternal circulation and were close to those in normal nonpregnant adults.
在整个妊娠晚期、分娩期间及产后，均对母体血浆中的促肾上腺皮质激素释放激素（CRH）进行了测定。同时，也对动脉和静脉脐带血血浆样本中的CRH水平进行了测定。在正常孕妇中，血浆CRH水平从妊娠28周时的50±15（±标准误）pg/mL（n = 41）升至40周时的1462±182 pg/mL（n = 55），分娩时为1680±101 pg/mL（n = 65）。患有妊娠高血压综合征的女性（n = 49）血浆CRH水平显著高于此正常范围。同样，随后发生早产的女性在分娩开始前几周其CRH水平就已升高。分娩后，血浆CRH在15小时内恢复正常。整个妊娠晚期血浆总皮质醇水平变化不大，但在分娩期间升高，并在产后2 - 3天内保持升高。因此，血浆皮质醇与CRH之间无相关性，这意味着这种胎盘CRH在妊娠期间并非主要参与母体下丘脑 - 垂体 - 肾上腺轴的调控。脐带血血浆样本中CRH的浓度明显低于母体循环中的浓度，且接近正常未孕成年人的水平。
