T细胞缺陷大鼠对实验性变应性神经炎诱导的易感性降低。

Reduced susceptibility of T cell-deficient rats to induction of experimental allergic neuritis.

作者信息

Brosnan J V, Craggs R I, King R H, Thomas P K

出版信息

J Neuroimmunol. 1987 Apr;14(3):267-82. doi: 10.1016/0165-5728(87)90014-2.

Abstract

Lewis rats were made deficient in T cells by adult thymectomy and lethal irradiation, and then reconstituted with T cell-free bone marrow. Their ability to develop experimental allergic neuritis (EAN) was compared with normal rats. The majority of T cell-deficient rats remained clinically and histologically unaffected, whereas all but one of the normal rats developed severe EAN. Those T cell-deficient animals which succumbed to EAN were found to have a significantly higher percentage of residual blood T lymphocytes than those which did not. Full susceptibility to EAN was restored by an inoculum of whole thoracic duct lymphocytes (TDL) from normal animals but not by TDL depleted of T cells. The results therefore provide direct confirmation that T cells are a requirement for the development of EAN.

摘要

通过成年大鼠胸腺切除和致死性照射使Lewis大鼠T细胞缺陷，然后用无T细胞的骨髓进行重建。将它们发生实验性变应性神经炎（EAN）的能力与正常大鼠进行比较。大多数T细胞缺陷大鼠在临床和组织学上未受影响，而除一只外的所有正常大鼠均发生了严重的EAN。那些死于EAN的T细胞缺陷动物的残余血液T淋巴细胞百分比明显高于未死于EAN的动物。用正常动物的全胸导管淋巴细胞（TDL）接种可恢复对EAN的完全易感性，但用去除T细胞的TDL接种则不能。因此，结果直接证实T细胞是EAN发生所必需的。