1,25-二羟维生素D对正常及绝经后骨质疏松症女性成骨细胞功能的刺激试验
1,25-Dihydroxyvitamin D stimulation test for osteoblast function in normal and osteoporotic postmenopausal women.
作者信息
Duda R J, Kumar R, Nelson K I, Zinsmeister A R, Mann K G, Riggs B L
出版信息
J Clin Invest. 1987 Apr;79(4):1249-53. doi: 10.1172/JCI112944.
Abstract
The cause of bone loss in postmenopausal osteoporosis--decreased bone formation or increased bone resorption--is controversial. Synthesis of bone--Gla protein (BGP), a specific osteoblast product, is stimulated by 1,25-dihydroxyvitamin D3 [1,25(OH)2D] in vitro. Thus, increases in serum BGP levels during 1,25(OH)2D administration might provide a useful dynamic index of osteoblast function. We compared 14 postmenopausal osteoporotic women with 12 age-matched postmenopausal normal women before and during 6 d of 1,25(OH)2D administration (2.0 micrograms/d). Serum BGP levels were similar at baseline and increased during treatment in both groups (P less than 0.001). However, trend analysis showed a greater (P less than 0.01) increase in the osteoporotic women. These data do not support the hypothesis that defective osteoblast function is the major cause of bone loss in postmenopausal osteoporosis.
摘要
绝经后骨质疏松症中骨质流失的原因——骨形成减少还是骨吸收增加——存在争议。骨钙素（BGP）是一种特定的成骨细胞产物，其在体外可被1,25 - 二羟维生素D3 [1,25(OH)2D]刺激合成。因此，在给予1,25(OH)2D期间血清BGP水平的升高可能提供一个有用的成骨细胞功能动态指标。我们在给予1,25(OH)2D（2.0微克/天）6天之前及期间，将14名绝经后骨质疏松女性与12名年龄匹配的绝经后正常女性进行了比较。两组在基线时血清BGP水平相似，且在治疗期间均升高（P < 0.001）。然而，趋势分析显示骨质疏松女性的升高幅度更大（P < 0.01）。这些数据不支持成骨细胞功能缺陷是绝经后骨质疏松症中骨质流失主要原因的假说。
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J Clin Invest. 1981 Feb;67(2):328-35. doi: 10.1172/JCI110039.
2
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Clin Sci (Lond). 1982 Aug;63(2):153-60. doi: 10.1042/cs0630153.
3
Postmenopausal osteoporosis. A heterogeneous disorder as assessed by histomorphometric analysis of Iliac crest bone from untreated patients.绝经后骨质疏松症。通过对未经治疗患者的髂嵴骨进行组织形态计量学分析评估，这是一种异质性疾病。
Am J Med. 1982 Feb;72(2):193-202. doi: 10.1016/0002-9343(82)90810-5.
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J Biol Chem. 1980 Dec 25;255(24):11660-3.
5
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