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1,25-Dihydroxyvitamin D stimulation test for osteoblast function in normal and osteoporotic postmenopausal women.1,25-二羟维生素D对正常及绝经后骨质疏松症女性成骨细胞功能的刺激试验
J Clin Invest. 1987 Apr;79(4):1249-53. doi: 10.1172/JCI112944.
2
Effect of a long-term treatment with 1,25-dihydroxyvitamin D3 on osteocalcin in postmenopausal osteoporosis.1,25 - 二羟基维生素D3长期治疗对绝经后骨质疏松症骨钙素的影响
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3
Short-term 1,25-dihydroxyvitamin D3 administration raises serum osteocalcin in patients with postmenopausal osteoporosis.
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The effects of high-dose glucocorticoid administration on serum bone gamma carboxyglutamic acid-containing protein, serum alkaline phosphatase and vitamin D metabolites in normal subjects.大剂量糖皮质激素给药对正常受试者血清骨γ-羧基谷氨酸蛋白、血清碱性磷酸酶及维生素D代谢产物的影响。
Bone Miner. 1988 Apr;4(1):105-13.
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Comparison of vitamin D metabolism in early healthy and late osteoporotic postmenopausal women.早期健康与晚期骨质疏松绝经后女性维生素D代谢的比较。
Calcif Tissue Int. 1990 Dec;47(6):332-7. doi: 10.1007/BF02555883.
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Assessment of bone turnover in postmenopausal osteoporosis by measurement of serum bone Gla-protein.通过测量血清骨钙素评估绝经后骨质疏松症患者的骨转换情况。
J Lab Clin Med. 1983 Oct;102(4):470-6.
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Idiopathic juvenile osteoporosis: evidence of normal osteoblast function by 1,25-dihydroxyvitamin D3 stimulation test.特发性青少年骨质疏松症：1,25 - 二羟维生素D3刺激试验显示成骨细胞功能正常的证据。
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Biochemical effects of calcium supplementation in postmenopausal osteoporosis.钙补充剂对绝经后骨质疏松症的生化影响。
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Serum bone Gla-protein: a specific marker for bone formation in postmenopausal osteoporosis.血清骨钙素：绝经后骨质疏松症骨形成的特异性标志物。
Lancet. 1984 May 19;1(8386):1091-3. doi: 10.1016/s0140-6736(84)92506-6.

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Recent advances in the use of serological bone formation markers to monitor callus development and fracture healing.使用血清学骨形成标志物监测骨痂发育和骨折愈合的最新进展。
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Dietary phylloquinone depletion and repletion in postmenopausal women: effects on bone and mineral metabolism.绝经后女性膳食叶绿醌的消耗与补充：对骨骼和矿物质代谢的影响。
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Long-term culture in dexamethasone unmasks an abnormal phenotype in osteoblasts isolated from osteoporotic subjects.在从骨质疏松症患者分离出的成骨细胞中，地塞米松长期培养会揭示出一种异常表型。
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Effects of active vitamin D3 and parathyroid hormone on the serum osteocalcin in idiopathic hypoparathyroidism and pseudohypoparathyroidism.活性维生素D3和甲状旁腺激素对特发性甲状旁腺功能减退症和假性甲状旁腺功能减退症患者血清骨钙素的影响。
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Suggestion of a deficient osteoblastic function in diabetes mellitus: the possible cause of osteopenia in diabetics.
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Sex- and age-related changes in bone and serum osteocalcin.
Calcif Tissue Int. 1990 Mar;46(3):179-82. doi: 10.1007/BF02555041.
8
Use of non-collagen markers in osteoporosis studies.非胶原蛋白标志物在骨质疏松症研究中的应用。
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Short-term course of 1,25(OH)2D3 stimulates osteoblasts but not osteoclasts in osteoporosis and osteoarthritis.1,25(OH)₂D₃ 的短期疗程可刺激骨质疏松症和骨关节炎中的成骨细胞，但不刺激破骨细胞。
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10
Idiopathic juvenile osteoporosis: evidence of normal osteoblast function by 1,25-dihydroxyvitamin D3 stimulation test.特发性青少年骨质疏松症：1,25 - 二羟维生素D3刺激试验显示成骨细胞功能正常的证据。
Calcif Tissue Int. 1992 Jul;51(1):20-3. doi: 10.1007/BF00296211.

本文引用的文献

1
Differential changes in bone mineral density of the appendicular and axial skeleton with aging: relationship to spinal osteoporosis.随着年龄增长，四肢骨骼与中轴骨骼骨密度的差异变化：与脊柱骨质疏松症的关系。
J Clin Invest. 1981 Feb;67(2):328-35. doi: 10.1172/JCI110039.
2
Rates of new bone formation in patients with crush fracture osteoporosis.压缩性骨折骨质疏松症患者的新骨形成率。
Clin Sci (Lond). 1982 Aug;63(2):153-60. doi: 10.1042/cs0630153.
3
Postmenopausal osteoporosis. A heterogeneous disorder as assessed by histomorphometric analysis of Iliac crest bone from untreated patients.绝经后骨质疏松症。通过对未经治疗患者的髂嵴骨进行组织形态计量学分析评估，这是一种异质性疾病。
Am J Med. 1982 Feb;72(2):193-202. doi: 10.1016/0002-9343(82)90810-5.
4
1,25-Dihydroxyvitamin D3 increases synthesis of the vitamin K-dependent bone protein by osteosarcoma cells.1,25-二羟基维生素D3可增加骨肉瘤细胞中维生素K依赖性骨蛋白的合成。
J Biol Chem. 1980 Dec 25;255(24):11660-3.
5
New biochemical marker for bone metabolism. Measurement by radioimmunoassay of bone GLA protein in the plasma of normal subjects and patients with bone disease.骨代谢的新型生化标志物。通过放射免疫分析法测定正常受试者和骨病患者血浆中的骨γ-羧基谷氨酸蛋白。
J Clin Invest. 1980 Nov;66(5):878-83. doi: 10.1172/JCI109954.
6
Mean wall thickness and formation periods of trabecular bone packets in idiopathic osteoporosis.特发性骨质疏松症中小梁骨包的平均壁厚度和形成期。
Calcif Tissue Int. 1981;33(3):199-204. doi: 10.1007/BF02409438.
7
Relationships between surface, volume, and thickness of iliac trabecular bone in aging and in osteoporosis. Implications for the microanatomic and cellular mechanisms of bone loss.衰老及骨质疏松症患者髂骨小梁骨的表面、体积与厚度之间的关系。对骨质流失的微观解剖学及细胞机制的启示。
J Clin Invest. 1983 Oct;72(4):1396-409. doi: 10.1172/JCI111096.
8
Urinary gamma-carboxyglutamic acid and serum osteocalcin as bone markers: studies in osteoporosis and Paget's disease.尿γ-羧基谷氨酸和血清骨钙素作为骨标志物：骨质疏松症和佩吉特病的研究
J Clin Endocrinol Metab. 1983 Dec;57(6):1221-5. doi: 10.1210/jcem-57-6-1221.
9
Assessment of bone turnover in postmenopausal osteoporosis by measurement of serum bone Gla-protein.通过测量血清骨钙素评估绝经后骨质疏松症患者的骨转换情况。
J Lab Clin Med. 1983 Oct;102(4):470-6.
10
Serum osteocalcin in the treatment of inherited rickets with 1,25-dihydroxyvitamin D3.
J Clin Endocrinol Metab. 1983 May;56(5):1063-7. doi: 10.1210/jcem-56-5-1063.

1,25-二羟维生素D对正常及绝经后骨质疏松症女性成骨细胞功能的刺激试验

1,25-Dihydroxyvitamin D stimulation test for osteoblast function in normal and osteoporotic postmenopausal women.

作者信息

Duda R J, Kumar R, Nelson K I, Zinsmeister A R, Mann K G, Riggs B L

出版信息

J Clin Invest. 1987 Apr;79(4):1249-53. doi: 10.1172/JCI112944.

DOI:10.1172/JCI112944
PMID:3494046
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC424323/
Abstract

The cause of bone loss in postmenopausal osteoporosis--decreased bone formation or increased bone resorption--is controversial. Synthesis of bone--Gla protein (BGP), a specific osteoblast product, is stimulated by 1,25-dihydroxyvitamin D3 [1,25(OH)2D] in vitro. Thus, increases in serum BGP levels during 1,25(OH)2D administration might provide a useful dynamic index of osteoblast function. We compared 14 postmenopausal osteoporotic women with 12 age-matched postmenopausal normal women before and during 6 d of 1,25(OH)2D administration (2.0 micrograms/d). Serum BGP levels were similar at baseline and increased during treatment in both groups (P less than 0.001). However, trend analysis showed a greater (P less than 0.01) increase in the osteoporotic women. These data do not support the hypothesis that defective osteoblast function is the major cause of bone loss in postmenopausal osteoporosis.

摘要

绝经后骨质疏松症中骨质流失的原因——骨形成减少还是骨吸收增加——存在争议。骨钙素（BGP）是一种特定的成骨细胞产物，其在体外可被1,25 - 二羟维生素D3 [1,25(OH)2D]刺激合成。因此，在给予1,25(OH)2D期间血清BGP水平的升高可能提供一个有用的成骨细胞功能动态指标。我们在给予1,25(OH)2D（2.0微克/天）6天之前及期间，将14名绝经后骨质疏松女性与12名年龄匹配的绝经后正常女性进行了比较。两组在基线时血清BGP水平相似，且在治疗期间均升高（P < 0.001）。然而，趋势分析显示骨质疏松女性的升高幅度更大（P < 0.01）。这些数据不支持成骨细胞功能缺陷是绝经后骨质疏松症中骨质流失主要原因的假说。