Blanco Rancés, Carrillo-Beltrán Diego, Corvalán Alejandro H, Aguayo Francisco
Programa de Virología, Instituto de Ciencias Biomédicas (ICBM), Facultad de Medicina, Universidad de Chile, Santiago 8380000, Chile.
Advanced Center for Chronic Diseases (ACCDiS), Pontificia Universidad Católica de Chile, Santiago 8320000, Chile.
Biology (Basel). 2021 Nov 26;10(12):1232. doi: 10.3390/biology10121232.
High-risk human papillomaviruses (HR-HPVs) and Epstein-Barr virus (EBV) are recognized oncogenic viruses involved in the development of a subset of head and neck cancers (HNCs). HR-HPVs are etiologically associated with a subset of oropharyngeal carcinomas (OPCs), whereas EBV is a recognized etiological agent of undifferentiated nasopharyngeal carcinomas (NPCs). In this review, we address epidemiological and mechanistic evidence regarding a potential cooperation between HR-HPV and EBV for HNC development. Considering that: (1) both HR-HPV and EBV infections require cofactors for carcinogenesis; and (2) both oropharyngeal and oral epithelium can be directly exposed to carcinogens, such as alcohol or tobacco smoke, we hypothesize possible interaction mechanisms. The epidemiological and experimental evidence suggests that HR-HPV/EBV cooperation for developing a subset of HNCs is plausible and warrants further investigation.
高危型人乳头瘤病毒（HR-HPVs）和爱泼斯坦-巴尔病毒（EBV）是公认的致癌病毒，与一部分头颈癌（HNCs）的发生有关。HR-HPVs在病因上与一部分口咽癌（OPCs）相关，而EBV是未分化鼻咽癌（NPCs）公认的致病因子。在本综述中，我们阐述了关于HR-HPV和EBV在HNC发生过程中潜在协同作用的流行病学和机制证据。鉴于：（1）HR-HPV和EBV感染致癌均需要辅助因子；（2）口咽和口腔上皮均可直接接触致癌物，如酒精或烟草烟雾，我们推测了可能的相互作用机制。流行病学和实验证据表明，HR-HPV/EBV协同作用导致一部分HNC发生是有道理的，值得进一步研究。
