Bertz Hartmut
Department of Medicine I, Hematology/Oncology/Stem Cell Transplantation, Faculty of Medicine, Medical Center, University of Freiburg, D-79106 Freiburg, Germany.
Cancers (Basel). 2021 Dec 8;13(24):6187. doi: 10.3390/cancers13246187.
The general population is getting older and suffer more haematological malignancies despite being physically fit. These malignancies are mainly only curable via an alloHCT, and they are now carried out more frequently. Patients benefit from intensive rehabilitation earlier and may need it repeatedly in cases of severe side effects (e.g., graft-versus-host disease). They can suffer many problems that other cancer patients do not experience, such as severe infections, continued immunosuppression, nutritional restrictions, acute or chronic GvHD, or organ impairments (e.g., lung, eyes). They may also encounter various associated psychological problems, e.g., feeling like a chimera. Rehabilitation centres willing to care for patients after alloHCT should have an experienced multidisciplinary team and should work in close co-operation with the primary transplant centre.
普通人群年龄在增长，尽管身体健康，但患血液系统恶性肿瘤的情况却增多了。这些恶性肿瘤主要只能通过异基因造血细胞移植（alloHCT）治愈，而且现在这种移植实施得更为频繁。患者能更早从强化康复中受益，并且在出现严重副作用（如移植物抗宿主病）的情况下可能需要反复进行康复治疗。他们会遭遇许多其他癌症患者未曾经历的问题，比如严重感染、持续的免疫抑制、营养限制、急性或慢性移植物抗宿主病（GvHD），或器官损伤（如肺部、眼睛）。他们还可能会遇到各种相关的心理问题，比如感觉自己像个嵌合体。愿意在alloHCT后照料患者的康复中心应该拥有一支经验丰富的多学科团队，并且应与初级移植中心密切合作。
