Thoma Oana-Maria, Neurath Markus F, Waldner Maximilian J
Department of Medicine 1, University Hospital Erlangen and Friedrich-Alexander University Erlangen-Nürnberg, 91052 Erlangen, Germany.
German Center for Immunotherapy (DZI), University Hospital Erlangen and Friedrich-Alexander University Erlangen-Nürnberg, 91052 Erlangen, Germany.
Cancers (Basel). 2021 Dec 11;13(24):6227. doi: 10.3390/cancers13246227.
Colorectal cancer (CRC) continues to be one of the most frequently diagnosed types of cancers in the world. CRC is considered to affect mostly elderly patients, and the number of diagnosed cases increases with age. Even though general screening improves outcomes, the overall survival and recurrence-free CRC rates in aged individuals are highly dependent on their history of comorbidities. Furthermore, aging is also known to alter the immune system, and especially the adaptive immune T cells. Many studies have emphasized the importance of T cell responses to CRC. Therefore, understanding how age-related changes affect the outcome in CRC patients is crucial. This review focuses on what is so far known about age-related T cell dysfunction in elderly patients with colorectal cancer and how aged T cells can mediate its development. Last, this study describes the advances in basic animal models that have potential to be used to elucidate the role of aged T cells in CRC.
结直肠癌（CRC）仍然是世界上最常被诊断出的癌症类型之一。CRC主要影响老年患者，确诊病例数随年龄增长而增加。尽管常规筛查可改善预后，但老年个体的总体生存率和无复发性CRC率高度依赖于其合并症病史。此外，衰老还会改变免疫系统，尤其是适应性免疫T细胞。许多研究都强调了T细胞反应对CRC的重要性。因此，了解与年龄相关的变化如何影响CRC患者的预后至关重要。本综述聚焦于目前已知的老年结直肠癌患者中与年龄相关的T细胞功能障碍，以及衰老的T细胞如何介导其发展。最后，本研究描述了基础动物模型的进展，这些模型有可能用于阐明衰老T细胞在CRC中的作用。
