Alhasan Khalid A, Shalaby Mohamed A, Temsah Mohamad-Hani, Aljamaan Fadi, Shagal Reem, AlFaadhel Talal, Alomi Mohammed, AlMatham Khalid, AlHerbish Adi J, Raina Rupesh, Sethi Sidharth K, Alsubaie Sarah, Hakami Marwah H, Alharbi Najla M, Shebeli Razan A, Nur Hanan Mohamed, Kashari Ohoud F, Qari Faiza A, Albanna Amr S, Kari Jameela A
Pediatrics Department, College of Medicine, King Saud University, Riyadh 11451, Saudi Arabia.
Pediatric Nephrology Center of Excellence, Department of Pediatrics, King Abdulaziz University, Jeddah 21589, Saudi Arabia.
Healthcare (Basel). 2021 Nov 23;9(12):1608. doi: 10.3390/healthcare9121608.
SARS-CoV-2 infection has a high mortality rate and continues to be a global threat, which warrants the identification of all mortality risk factors in critically ill patients.
This is a retrospective multicenter cohort study conducted in five hospitals in the Kingdom of Saudi Arabia (KSA). We enrolled patients with confirmed SARS-COV-2 infection admitted to any of the intensive care units from the five hospitals between March 2020 and July 2020, corresponding to the peak of recorded COVID-19 cases in the KSA.
In total, 229 critically ill patients with confirmed SARS-CoV-2 infection were included in the study. The presenting symptoms and signs of patients who died during hospitalization were not significantly different from those observed among patients who survived. The baseline comorbidities that were significantly associated with in-hospital mortality were diabetes (62% vs. 48% among patients who died and survived ( = 0.046)), underlying cardiac disease (38% vs. 19% ( = 0.001)), and underlying kidney disease (32% vs. 12% ( < 0.001)).
In our cohort, the baseline comorbidities that were significantly associated with in-hospital mortality were diabetes, underlying cardiac disease, and underlying kidney disease. Additionally, the factors that independently influenced mortality among critically ill COVID-19 patients were high Activated Partial Thromboplastin Time (aPTT )and international normalization ratio (INR), acidosis, and high ferritin.
严重急性呼吸综合征冠状病毒2（SARS-CoV-2）感染死亡率高，仍是全球威胁，这就需要确定重症患者的所有死亡风险因素。
这是一项在沙特阿拉伯王国五家医院开展的回顾性多中心队列研究。我们纳入了2020年3月至2020年7月期间在这五家医院的任何重症监护病房收治的确诊SARS-CoV-2感染患者，这一时期对应沙特阿拉伯王国记录的新冠病例高峰期。
该研究共纳入229例确诊SARS-CoV-2感染的重症患者。住院期间死亡患者的症状和体征与存活患者相比无显著差异。与院内死亡显著相关的基线合并症有糖尿病（死亡患者和存活患者分别为62%和48%（P = 0.046））、基础心脏病（38%和19%（P = 0.001））以及基础肾病（32%和12%（P < 0.001））。
在我们的队列中，与院内死亡显著相关的基线合并症为糖尿病、基础心脏病和基础肾病。此外，独立影响重症新冠患者死亡率的因素为活化部分凝血活酶时间（aPTT）和国际标准化比值（INR）升高、酸中毒以及铁蛋白升高。
