人体冠状动脉狭窄的几何尺寸与心肌灌注储备之间的关系。
Relation between geometric dimensions of coronary artery stenoses and myocardial perfusion reserve in man.
作者信息
Goldstein R A, Kirkeeide R L, Demer L L, Merhige M, Nishikawa A, Smalling R W, Mullani N A, Gould K L
出版信息
J Clin Invest. 1987 May;79(5):1473-8. doi: 10.1172/JCI112976.
Abstract
To determine the relation between stenosis anatomy and perfusion in man, 31 patients had quantitative coronary arteriography and positron imaging (PET) with Rb-82 or N-13 ammonia at rest and after dipyridamole-handgrip stress. 10 patients were also studied after angioplasty (total stenoses = 41). Percent narrowing and absolute cross-sectional luminal area were related through a quadratic function to myocardial perfusion reserve determined with PET. Arteriographically determined coronary flow reserve was linearly related to relative myocardial perfusion reserve as expected, based on the derivation of equations for stenosis flow reserve. All of the correlations had considerable scatter, indicating that no single measurement derived by coronary arteriography was a good indicator of perfusion reserve by PET in individual patients. This study provides the relation between all anatomic dimensions of coronary artery stenoses and myocardial perfusion reserve in man, and suggests that PET indicates the functional significance of coronary artery stenoses for clinical purposes.
摘要
为了确定人体狭窄解剖结构与灌注之间的关系，31例患者在静息状态下以及双嘧达莫 - 握力应激后接受了定量冠状动脉造影和用铷 - 82或氮 - 13氨进行的正电子成像（PET）检查。其中10例患者在血管成形术后也进行了研究（总狭窄数 = 41）。狭窄百分比和绝对管腔横截面积通过二次函数与用PET测定的心肌灌注储备相关。根据狭窄血流储备方程的推导，血管造影确定的冠状动脉血流储备与相对心肌灌注储备呈线性相关，正如预期的那样。所有相关性都有相当大的离散度，这表明通过冠状动脉造影得出的单一测量值在个体患者中并非PET灌注储备的良好指标。本研究提供了人体冠状动脉狭窄的所有解剖学维度与心肌灌注储备之间的关系，并表明PET可用于临床目的指示冠状动脉狭窄的功能意义。
相似文献
1
Relation between geometric dimensions of coronary artery stenoses and myocardial perfusion reserve in man.人体冠状动脉狭窄的几何尺寸与心肌灌注储备之间的关系。
J Clin Invest. 1987 May;79(5):1473-8. doi: 10.1172/JCI112976.
2
Noninvasive assessment of coronary stenoses by myocardial perfusion imaging during pharmacologic coronary vasodilation. VIII. Clinical feasibility of positron cardiac imaging without a cyclotron using generator-produced rubidium-82.在药物性冠状动脉扩张期间通过心肌灌注成像对冠状动脉狭窄进行无创评估。VIII. 使用发生器产生的铷-82 进行无需回旋加速器的正电子心脏成像的临床可行性。
J Am Coll Cardiol. 1986 Apr;7(4):775-89. doi: 10.1016/s0735-1097(86)80336-9.
3
Assessment of coronary stenoses by myocardial perfusion imaging during pharmacologic coronary vasodilation. VII. Validation of coronary flow reserve as a single integrated functional measure of stenosis severity reflecting all its geometric dimensions.在药物性冠状动脉血管扩张期间通过心肌灌注成像评估冠状动脉狭窄。VII. 冠状动脉血流储备作为反映狭窄严重程度所有几何维度的单一综合功能指标的验证。
J Am Coll Cardiol. 1986 Jan;7(1):103-13. doi: 10.1016/s0735-1097(86)80266-2.
4
Changes in myocardial perfusion reserve after PTCA: noninvasive assessment with positron tomography.
J Nucl Med. 1987 Aug;28(8):1262-7.
5
Relation among stenosis severity, myocardial blood flow, and flow reserve in patients with coronary artery disease.冠心病患者狭窄严重程度、心肌血流量与血流储备之间的关系。
Circulation. 1995 Apr 1;91(7):1944-51. doi: 10.1161/01.cir.91.7.1944.
6
Role of relative myocardial perfusion reserve for evaluating stenosis severity in patients with single-vessel coronary artery disease using.相对心肌灌注储备在使用……评估单支冠状动脉疾病患者狭窄严重程度中的作用
Jpn Circ J. 2001 Jan;65(1):23-7. doi: 10.1253/jcj.65.23.
7
Changes in myocardial perfusion abnormalities by positron emission tomography after long-term, intense risk factor modification.长期、强化危险因素干预后，正电子发射断层扫描显示的心肌灌注异常变化。
JAMA. 1995 Sep 20;274(11):894-901. doi: 10.1001/jama.1995.03530110056036.
8
Structural abnormalities of the coronary arterial wall--in addition to luminal narrowing--affect myocardial blood flow reserve.冠状动脉壁的结构异常——除了管腔狭窄外——还会影响心肌血流储备。
J Nucl Med. 2011 Nov;52(11):1704-12. doi: 10.2967/jnumed.111.091009. Epub 2011 Sep 19.
9
Detecting and assessing severity of coronary artery disease in humans.
Cardiovasc Intervent Radiol. 1990 Feb-Mar;13(1):5-13. doi: 10.1007/BF02576930.
10
Frequency and clinical implications of fluid dynamically significant diffuse coronary artery disease manifest as graded, longitudinal, base-to-apex myocardial perfusion abnormalities by noninvasive positron emission tomography.通过无创正电子发射断层扫描显示为分级、纵向、从心底到心尖心肌灌注异常的血流动力学显著的弥漫性冠状动脉疾病的频率及临床意义。
Circulation. 2000 Apr 25;101(16):1931-9. doi: 10.1161/01.cir.101.16.1931.
引用本文的文献
1
Myocardial blood flow is the dominant factor influencing cardiac magnetic resonance adenosine stress T2.心肌血流是影响心脏磁共振腺苷负荷 T2 的主导因素。
NMR Biomed. 2022 Mar;35(3):e4643. doi: 10.1002/nbm.4643. Epub 2021 Nov 17.
2
Clinical Quantification of Myocardial Blood Flow Using PET: Joint Position Paper of the SNMMI Cardiovascular Council and the ASNC.使用正电子发射断层扫描（PET）对心肌血流进行临床定量：SNMMI心血管委员会和ASNC的联合立场文件
J Nucl Cardiol. 2018 Feb;25(1):269-297. doi: 10.1007/s12350-017-1110-x.
3
Relations between location and type of intracranial atherosclerosis and parenchymal damage.颅内动脉粥样硬化的位置、类型与实质损害之间的关系。
J Cereb Blood Flow Metab. 2016 Jul;36(7):1271-80. doi: 10.1177/0271678X15616401. Epub 2015 Nov 11.
4
Transmural myocardial perfusion gradients in relation to coronary artery stenoses severity assessed by cardiac multidetector computed tomography.通过心脏多排螺旋计算机断层扫描评估的与冠状动脉狭窄严重程度相关的透壁心肌灌注梯度
Int J Cardiovasc Imaging. 2015 Jan;31(1):171-80. doi: 10.1007/s10554-014-0530-9. Epub 2014 Sep 7.
5
Fractional flow reserve-guided percutaneous coronary intervention: does coronary pressure never lie?血流储备分数指导下的经皮冠状动脉介入治疗：冠状动脉压力永远不会说谎吗？
Curr Treat Options Cardiovasc Med. 2014 Apr;16(4):294. doi: 10.1007/s11936-014-0294-5.
6
Diagnostic accuracy of stress perfusion CMR in comparison with quantitative coronary angiography: fully quantitative, semiquantitative, and qualitative assessment.与定量冠状动脉造影相比，应力灌注心脏磁共振成像的诊断准确性：全定量、半定量和定性评估。
JACC Cardiovasc Imaging. 2014 Jan;7(1):14-22. doi: 10.1016/j.jcmg.2013.08.014.
7
Quantitative cardiac positron emission tomography: the time is coming!定量心脏正电子发射断层扫描：时机即将到来！
Scientifica (Cairo). 2012;2012:948653. doi: 10.6064/2012/948653. Epub 2012 Aug 27.
8
Method for percutaneously introducing, and removing, anatomical stenosis of predetermined severity in vivo: the "stenotic stent".经皮引入和移除体内预定严重程度的解剖狭窄的方法：“狭窄支架”。
J Cardiovasc Transl Res. 2013 Aug;6(4):640-8. doi: 10.1007/s12265-013-9476-x. Epub 2013 Jun 4.
9
Quantitative PET/CT measures of myocardial flow reserve and atherosclerosis for cardiac risk assessment and predicting adverse patient outcomes.定量 PET/CT 心肌血流储备和动脉粥样硬化评估心脏风险和预测不良患者结局的研究进展。
Curr Cardiol Rep. 2013 Mar;15(3):344. doi: 10.1007/s11886-012-0344-0.
10
Incremental prognostic value of coronary flow reserve assessed with single-photon emission computed tomography.单光子发射计算机断层扫描评估冠状动脉血流储备的增量预后价值。
J Nucl Cardiol. 2011 Aug;18(4):541-3. doi: 10.1007/s12350-011-9408-6.
本文引用的文献
1
Experimental validation of quantitative coronary arteriography for determining pressure-flow characteristics of coronary stenosis.
Circulation. 1982 Nov;66(5):930-7. doi: 10.1161/01.cir.66.5.930.
2
The value of lesion cross-sectional area determined by quantitative coronary angiography in assessing the physiologic significance of proximal left anterior descending coronary arterial stenoses.
Circulation. 1984 Jun;69(6):1111-9. doi: 10.1161/01.cir.69.6.1111.
3
Myocardial perfusion with rubidium-82. II. Effects of metabolic and pharmacologic interventions.
J Nucl Med. 1983 Oct;24(10):907-15.
4
Myocardial perfusion with rubidium-82. I. Measurement of extraction fraction and flow with external detectors.用铷-82进行心肌灌注。I. 用外部探测器测量提取分数和血流量。
J Nucl Med. 1983 Oct;24(10):898-906.
5
Myocardial perfusion with rubidium-82: III. Theory relating severity of coronary stenosis to perfusion deficit.
J Nucl Med. 1984 Nov;25(11):1190-6.
6
Effects of coronary stenoses on coronary flow reserve and resistance.冠状动脉狭窄对冠状动脉血流储备和阻力的影响。
Am J Cardiol. 1974 Jul;34(1):48-55. doi: 10.1016/0002-9149(74)90092-7.
7
Physiologic basis for assessing critical coronary stenosis. Instantaneous flow response and regional distribution during coronary hyperemia as measures of coronary flow reserve.评估严重冠状动脉狭窄的生理学基础。冠状动脉充血时的瞬时血流反应和区域分布作为冠状动脉血流储备的指标。
Am J Cardiol. 1974 Jan;33(1):87-94. doi: 10.1016/0002-9149(74)90743-7.
8
Kinetics of rubidium-82 after coronary occlusion and reperfusion. Assessment of patency and viability in open-chested dogs.冠状动脉闭塞和再灌注后铷-82的动力学。开胸犬血管通畅性和心肌存活性的评估。
J Clin Invest. 1985 Apr;75(4):1131-7. doi: 10.1172/JCI111807.
9
Assessment of coronary stenoses by myocardial perfusion imaging during pharmacologic coronary vasodilation. VII. Validation of coronary flow reserve as a single integrated functional measure of stenosis severity reflecting all its geometric dimensions.在药物性冠状动脉血管扩张期间通过心肌灌注成像评估冠状动脉狭窄。VII. 冠状动脉血流储备作为反映狭窄严重程度所有几何维度的单一综合功能指标的验证。
J Am Coll Cardiol. 1986 Jan;7(1):103-13. doi: 10.1016/s0735-1097(86)80266-2.
10
Measurement of regional myocardial blood flow with N-13 ammonia and positron-emission tomography in intact dogs.
J Am Coll Cardiol. 1985 Jan;5(1):92-100. doi: 10.1016/s0735-1097(85)80089-9.
Zotero 插件