Sebban C, Wauquier I, Leredde A, Goujon Y, Venet R, Reisner C, Berthaux P
Pathol Biol (Paris). 1977 Dec;25(10):723-7.
Isolated, perfused hearts from 16 rats aged from 13 to 17 months were studied to examine the effects of age and of the compliance of the ejection circuit on heart rate and cardiac function curves. Heart rate was found to diminish both with age and with decreasing compliance of the ejection circuit. Cardiac function curves were also substantially modified by these two factors. It was found that old hearts adapted better to a reduced circuit compliance. This suggests that, in the intact animal, changes in the mechanical properties of the heart muscle may be an adjustment to the reduction in arterial compliance which accompanies ageing.
对16只年龄在13至17个月之间的大鼠的离体灌流心脏进行了研究，以考察年龄和射血循环顺应性对心率和心功能曲线的影响。结果发现，心率会随着年龄增长以及射血循环顺应性的降低而下降。这两个因素也会使心功能曲线发生显著改变。研究发现，老年心脏对降低的循环顺应性具有更好的适应性。这表明，在完整动物体内，心肌机械性能的变化可能是对衰老过程中伴随的动脉顺应性降低的一种调节。
