Department of Obstetrics and Gynecology, Hospital Universitario La Paz, 28046 Madrid, Spain.
Department of Pediatrics, Hospital Universitario Gregorio Marañón, 28007 Madrid, Spain.
Int J Environ Res Public Health. 2021 Dec 12;18(24):13117. doi: 10.3390/ijerph182413117.
Maternal age is related to a higher risk of adverse maternal, fetal, and neonatal outcomes in twin pregnancies. However, whether this increase in adverse outcomes is due solely to age or due to risk factors that are more common in women over 40 remains unknown. The aim of this study is to assess if maternal age over 40 years old is an independent risk factor for obstetric adverse outcomes in dichorionic diamniotic twin gestations. In this single-center retrospective cohort study, we compared the obstetric outcomes of women with dichorionic diamniotic twin pregnancies below and over 40 years of age. A twin pregnancy cohort enrolled between 2013 and 2019 was included in the study. Maternal, fetal, and labor complications were recorded. A total of 510 women were analyzed in two groups: 266 women below 40 years old and 244 women over 40 years old. Maternal age over 40 increased the odds of maternal (aOR = 1.9 (1.3; 2.9); -value = 0.002), fetal (aOR = 1.8 (1.0; 3.0); -value = 0.037), and labor complications (aOR = 2.5 (1.3; 4.6); -value = 0.004). Maternal age over 40 years was the most important factor increasing the odds of having a caesarean section (C-section). Over 40 years old was an independent risk factor for complications in dichorionic diamniotic twin pregnancies.
母亲年龄与双胎妊娠的不良母婴、胎儿和新生儿结局风险增加有关。然而，这种不良结局的增加是仅由于年龄还是由于 40 岁以上妇女更常见的危险因素尚不清楚。本研究旨在评估 40 岁以上母亲年龄是否是双绒毛膜双羊膜囊双胎妊娠产科不良结局的独立危险因素。在这项单中心回顾性队列研究中，我们比较了年龄在 40 岁以下和 40 岁以上的双绒毛膜双羊膜囊双胎妊娠的产科结局。研究纳入了 2013 年至 2019 年期间的双胎妊娠队列。记录了母亲、胎儿和分娩并发症。共有 510 名妇女分为两组进行分析：266 名年龄在 40 岁以下，244 名年龄在 40 岁以上。母亲年龄超过 40 岁增加了母亲（aOR = 1.9（1.3；2.9）；-值 = 0.002）、胎儿（aOR = 1.8（1.0；3.0）；-值 = 0.037）和分娩并发症（aOR = 2.5（1.3；4.6）；-值 = 0.004）的发生几率。母亲年龄超过 40 岁是增加剖宫产（C -section）几率的最重要因素。40 岁以上是双绒毛膜双羊膜囊双胎妊娠并发症的独立危险因素。
