由生长因子同源区域介导的低密度脂蛋白受体的酸依赖性配体解离与再循环
Acid-dependent ligand dissociation and recycling of LDL receptor mediated by growth factor homology region.
作者信息
Davis C G, Goldstein J L, Südhof T C, Anderson R G, Russell D W, Brown M S
出版信息
Nature. 1987;326(6115):760-5. doi: 10.1038/326760a0.
DOI:10.1038/326760a0
PMID:3494949
Abstract
A domain in the low-density lipoprotein receptor contains three cysteine-rich 'growth factor' repeats like those that occur in many proteins. When this domain is deleted, the receptor no longer releases its ligand at acid pH, it is no longer recycled efficiently and it is rapidly degraded after ligand binding.
摘要
低密度脂蛋白受体中的一个结构域包含三个富含半胱氨酸的“生长因子”重复序列，类似于许多蛋白质中出现的那些重复序列。当这个结构域被删除时，受体在酸性pH值下不再释放其配体，不再有效地循环利用，并且在配体结合后迅速降解。
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