Alstead E M, Grime J S, Critchley M, Morris A I, Gilmore I T, Ware J
Nucl Med Commun. 1987 Jan;8(1):33-43. doi: 10.1097/00006231-198701000-00005.
SPECT of the spleen has been performed with 99Tcm-sulphur colloid in 53 patients, and SPECT of the liver has been performed in 57 patients. All patients had histologically proven liver disease and were classified by the degree of severity, Group A-severe, Group B-moderate, Group C-mild. The patients were further classified as cirrhotic and non-cirrhotic. Eight controls were also studied. There is positive though poor correlation between splenic volume and uptake (r2 = 0.55). Splenic volume and uptake are significantly different in Group A patients compared with all other groups (p less than 0.001). They are also significantly different in cirrhotics versus non-cirrhotics and cirrhotics versus controls (p less than 0.001). Splenic SPECT was unhelpful in distinguishing between moderate and mild liver disease. SPECT of the spleen is a time consuming technique but a useful adjunct to liver SPECT in patients with portal hypertension.
对53例患者进行了99锝-硫胶体脾脏单光子发射计算机断层扫描（SPECT），对57例患者进行了肝脏SPECT检查。所有患者均经组织学证实患有肝脏疾病，并根据严重程度进行分类，A组-重度，B组-中度，C组-轻度。患者进一步分为肝硬化组和非肝硬化组。还对8名对照者进行了研究。脾脏体积与摄取之间存在正相关但相关性较差（r2 = 0.55）。与所有其他组相比，A组患者的脾脏体积和摄取量有显著差异（p < 0.001）。肝硬化患者与非肝硬化患者以及肝硬化患者与对照者之间也有显著差异（p < 0.001）。脾脏SPECT在区分中度和轻度肝脏疾病方面无帮助。脾脏SPECT是一项耗时的技术，但对于门静脉高压患者，它是肝脏SPECT的有用辅助手段。
