Jung Na-Yeon, Shin Jeong-Hyeon, Kim Hee Jin, Jang Hyemin, Moon Seung Hwan, Kim Seung Joo, Kim Yeshin, Cho Soo Hyun, Kim Ko Woon, Kim Jun Pyo, Jung Young Hee, Kim Sung Tae, Kim Eun-Joo, Na Duk L, Vogel Jacob W, Lee Sangjin, Seong Joon-Kyung, Seo Sang Won
Department of Neurology, Pusan National University Yangsan Hospital, Pusan National University School of Medicine and Research Institute for Convergence of Biomedical Science and Technology, Yangsan, South Korea.
School of Biomedical Engineering, Korea University, Seoul, South Korea.
Front Neurol. 2021 Dec 7;12:762251. doi: 10.3389/fneur.2021.762251. eCollection 2021.
We investigated the mediation effects of subcortical volume change in the relationship of amyloid beta (Aβ) and lacune with cognitive function in patients with mild cognitive impairment (MCI). We prospectively recruited 101 patients with MCI who were followed up with neuropsychological tests, MRI, or Pittsburgh compound B (PiB) PET for 3 years. The mediation effect of subcortical structure on the association of PiB or lacunes with cognitive function was analyzed using mixed effects models. Volume changes in the amygdala and hippocampus partially mediated the effect of PiB changes on memory function (direct effect = -0.168/-0.175, indirect effect = -0.081/-0.077 for amygdala/hippocampus) and completely mediated the effect of PiB changes on clinical dementia rating scale sum of the box (CDR-SOB) (indirect effect = 0.082/0.116 for amygdala/hippocampus). Volume changes in the thalamus completely mediated the effect of lacune on memory, frontal executive functions, and CDR-SOB (indirect effect = -0.037, -0.056, and 0.047, respectively). Our findings provide a better understanding of the distinct role of subcortical structures in the mediation of the relationships of amyloid or vascular changes with a decline in specific cognitive domains.
我们研究了皮质下体积变化在轻度认知障碍（MCI）患者中淀粉样β蛋白（Aβ）和腔隙与认知功能关系中的中介作用。我们前瞻性招募了101例MCI患者，对其进行神经心理学测试、MRI或匹兹堡化合物B（PiB）PET随访3年。使用混合效应模型分析皮质下结构对PiB或腔隙与认知功能关联的中介作用。杏仁核和海马体的体积变化部分介导了PiB变化对记忆功能的影响（杏仁核/海马体的直接效应=-0.168/-0.175，间接效应=-0.081/-0.077），并完全介导了PiB变化对临床痴呆评定量表框总和（CDR-SOB）的影响（杏仁核/海马体的间接效应=0.082/0.116）。丘脑的体积变化完全介导了腔隙对记忆、额叶执行功能和CDR-SOB的影响（间接效应分别为-0.037、-0.056和0.047）。我们的研究结果有助于更好地理解皮质下结构在淀粉样蛋白或血管变化与特定认知领域衰退关系的中介作用中的独特作用。
