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伴有慢性纹状体病和尾状核萎缩的复发性面部局灶性癫痫发作——一位老年糖尿病女性的双重打击

Recurrent Facial Focal Seizures With Chronic Striatopathy and Caudate Atrophy-A Double Whammy in an Elderly Woman With Diabetes Mellitus.

作者信息

Chatterjee Subhankar, Ghosh Ritwik, Ojha Umesh Kumar, Biswas Payel, Benito-León Julián, Dubey Souvik

机构信息

Department of General Medicine, Patliputra Medical College & Hospital, Dhanbad, Jharkhand, India.

Department of General Medicine, Burdwan Medical College & Hospital, Burdwan, West Bengal, India.

出版信息

Neurohospitalist. 2022 Jan;12(1):147-150. doi: 10.1177/19418744211035370. Epub 2021 Jul 23.

Abstract

Seizures and involuntary movements are relatively rare, but well-known neurological complications of non-ketotic hyperglycemia. While hemichorea-hemiballism secondary to diabetic striatopathy is increasingly being reported, unilateral caudate atrophy resulting from chronic vascular insufficiency/insult in a backdrop of poorly controlled diabetes mellitus is sparsely described in literature. We herein report a 75-year-old woman with poorly controlled diabetes mellitus who presented with concurrent epilepsia partialis continua involving left side of her face and hemichorea on the right side in the context of non-ketotic hyperglycemia. Neuroimaging revealed a space-occupying lesion suggestive of low-grade glioma in the right superior frontal cortex and left-sided caudate atrophy as well. Possibly, space-occupying lesion in motor cortex acted as an inciting factor for seizures and non-ketotic hyperglycemia further lowered the seizures threshold. On the other hand, atrophied left caudate had led to persistent choreiform movements secondary to chronic uncontrolled hyperglycemia. The simultaneous presence of acute and chronic neurological complications of diabetes mellitus makes this case unique. It also highlights the need for strict control of blood glucose and utility of appropriate neuroimaging to rapidly diagnose and prevent further complications.

摘要

癫痫发作和不自主运动相对罕见,但却是非酮症高血糖症众所周知的神经并发症。虽然糖尿病性纹状体病继发的偏侧舞蹈症-偏侧投掷症的报道越来越多,但在文献中,糖尿病控制不佳背景下慢性血管供血不足/损伤导致的单侧尾状核萎缩却鲜有描述。我们在此报告一名75岁糖尿病控制不佳的女性,在非酮症高血糖的情况下,出现累及左侧面部的持续性部分性癫痫发作并伴有右侧偏侧舞蹈症。神经影像学显示右侧额上回有一个占位性病变,提示为低度胶质瘤,左侧尾状核也有萎缩。可能运动皮层的占位性病变是癫痫发作的诱发因素,而非酮症高血糖进一步降低了癫痫阈值。另一方面,萎缩的左侧尾状核导致了慢性血糖控制不佳继发的持续性舞蹈样动作。糖尿病急性和慢性神经并发症同时出现使得该病例具有独特性。这也凸显了严格控制血糖的必要性以及适当神经影像学检查在快速诊断和预防进一步并发症方面的作用。

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