Mattrey R F, Hajek P C, Gylys-Morin V M, Baker L L, Martin J, Long D C, Long D M
AJR Am J Roentgenol. 1987 Jun;148(6):1259-63. doi: 10.2214/ajr.148.6.1259.
The ability to distinguish bowel from other intraabdominal structures is essential for the accurate diagnosis of intraabdominal disease with MR. Because perfluorochemicals have no protons, they cause no MR signal. Since they are immiscible with water, they create a signal void in bowel independent of bowel contents and thus are suitable as oral contrast agents. Furthermore, they are tasteless and odorless and have no side effects. We evaluated the use of perfluorochemicals by performing MR scans of the abdomen in rats after the oral administration of unemulsified perfluorohexylbromide or perfluoroctylbromide. Since the latter is approved as an investigational drug for oral use in humans, two volunteers were also studied. Both compounds created signal void in the bowel of both rats and human subjects allowing identification of the gastrointestinal tract. The results suggest that these compounds have potential as oral contrast agents for MR imaging.
利用磁共振成像（MR）准确诊断腹腔疾病时，区分肠管与其他腹腔内结构的能力至关重要。由于全氟化合物不含质子，因此不会产生MR信号。由于它们与水不混溶，所以在肠管中会形成信号缺失，与肠内容物无关，因此适合用作口服造影剂。此外，它们无味、无臭且无副作用。我们通过对口服未乳化的全氟己基溴或全氟辛基溴后的大鼠进行腹部MR扫描，评估了全氟化合物的用途。由于后者被批准作为人类口服的研究性药物，因此还对两名志愿者进行了研究。两种化合物在大鼠和人类受试者的肠管中均产生了信号缺失，从而能够识别胃肠道。结果表明，这些化合物有潜力作为MR成像的口服造影剂。
