University of Surrey, Daphne Jackson Road, Guildford, GU2 7WG, UK.
Royal Surrey NHS Foundation Trust, Egerton Road, Guildford, GU2 7XX, UK.
Cancer Metastasis Rev. 2022 Mar;41(1):211-242. doi: 10.1007/s10555-021-10002-6. Epub 2021 Dec 24.
The objective of the study was to document the effect of adipocytokines on endometrial cancer progression. A search of the databases CINAHL, Medline, PubMed, Cochrane, Web of Science, Embase and Google Scholar was performed for English language articles from January 2000 to December 2020 using the keywords: (Endometrial cancer) AND (progression OR metastasis) AND (adipocytokine OR adiponectin OR leptin OR visfatin OR IL-6 OR TNF-α OR adipokine OR cytokine). Forty-nine studies on adipocytokines have been included in this review. Adiponectin has been linked with anti-proliferative and anti-metastatic effects on endometrial cancer cells and is associated with a better prognosis. Leptin, visfatin and resistin are linked to the stimulation of endometrial cancer growth, proliferation, invasion and metastasis and are associated with worse prognosis or with a higher grade/stage of endometrial cancer. IL-6, Il-11, IL-31, IL-33, TNF-α, TGF-β1, SDF-1 and CXCR are involved in endometrial cancer cell growth and metastasis or involved in epithelial mesenchymal transformation (EMT) or associated with advanced disease. Adipocytokines have been found to directly impact endometrial cancer cell proliferation, invasion and migration. These molecules and their signalling pathways may be used to determine prognosis and course of the disease and may also be exploited as potential targets for cancer treatment and prevention of progression.
本研究旨在记录脂肪细胞因子对子宫内膜癌进展的影响。使用关键词：（子宫内膜癌）和（进展或转移）和（脂肪细胞因子或脂联素或瘦素或内脂素或 IL-6 或 TNF-α 或脂联素或细胞因子），对 2000 年 1 月至 2020 年 12 月的 CINAHL、Medline、PubMed、Cochrane、Web of Science、Embase 和 Google Scholar 数据库中的英文文章进行了检索。本综述共纳入 49 项关于脂肪细胞因子的研究。脂联素与子宫内膜癌细胞的抗增殖和抗转移作用有关，并与较好的预后相关。瘦素、内脂素和抵抗素与子宫内膜癌的生长、增殖、侵袭和转移的刺激有关，与较差的预后或子宫内膜癌的更高分级/分期有关。IL-6、IL-11、IL-31、IL-33、TNF-α、TGF-β1、SDF-1 和 CXCR 参与子宫内膜癌细胞的生长和转移，或参与上皮间质转化（EMT），或与晚期疾病有关。已经发现脂肪细胞因子直接影响子宫内膜癌细胞的增殖、侵袭和迁移。这些分子及其信号通路可用于确定预后和疾病进程，也可作为癌症治疗和预防进展的潜在靶点。
