Centre for Obesity Research and Education (CORE), School of Pharmacy and Life Sciences, Robert Gordon University, Garthdee Road, Aberdeen AB107GJ, United Kingdom of Great Britain and Northern Ireland; Royal Surrey County Hospital, Egerton Road, Guildford, Surrey GU2 7XX, United Kingdom of Great Britain and Northern Ireland.
Centre for Obesity Research and Education (CORE), School of Pharmacy and Life Sciences, Robert Gordon University, Garthdee Road, Aberdeen AB107GJ, United Kingdom of Great Britain and Northern Ireland.
Gynecol Oncol. 2020 Aug;158(2):507-516. doi: 10.1016/j.ygyno.2020.05.033. Epub 2020 Jun 5.
To investigate the association between circulating levels of adipocytokines (adiponectin, leptin, tumour necrosis factor alpha (TNFα), interleukin 6 (IL-6)) and growth factors (insulin-like growth factor I (IGF-I) and II (IGF-II)), and the risk of endometrial cancer.
Cochrane, CINAHL, Embase, Medline and Web of Science were searched for English-language manuscripts published between January 2000 and August 2018 using the following string of words: cancer and endometrial and (obesity or BMI) and (adiponectin or TNF* or IGF-I or IGF-II or IL-6 or leptin).
Twenty articles were included in this meta-analysis, which corresponded to 18 studies involving 2921 endometrial carcinoma cases and 5302 controls. Fourteen articles reported circulating levels for adiponectin, seven for leptin, three for TNFα, three for IL-6 and one for IGF-I. No article reported values for IGF-II. Patients with circulating adiponectin levels in the highest tertile had decreased endometrial cancer risk compared to women with levels in the lowest tertile, (summary of odds ratio (SOR) 0.51, 95% confidence interval (CI): 0.38-0.69, p < 0.00001). Women with circulating leptin concentrations in the highest tertile had increased endometrial cancer risk compared to women with concentrations in the lowest tertile (SOR 2.19, 95% CI: 1.45-3.30, p = 0.0002). There was no difference in cancer risk between participants with the highest TNFα and IL-6 levels compared to the lowest levels (SOR 1.27, 95% CI: 0.88-1.83, p = 0.20 and SOR 1.20, 95% CI: 0.89-1.63, p = 0.23, respectively).
Endometrial cancer risk is inversely affected by adiponectin and leptin levels. There appears to be no relationship between TNFα and IL-6 and the overall risk of endometrial cancer.
探讨循环脂肪细胞因子（脂联素、瘦素、肿瘤坏死因子-α（TNFα）、白细胞介素 6（IL-6））和生长因子（胰岛素样生长因子 I（IGF-I）和 II（IGF-II））水平与子宫内膜癌风险之间的关联。
检索了 Cochrane、CINAHL、Embase、Medline 和 Web of Science 数据库，使用以下字符串检索了 2000 年 1 月至 2018 年 8 月期间发表的英文文献：癌症和子宫内膜和（肥胖或 BMI）和（脂联素或 TNF*或 IGF-I 或 IGF-II 或 IL-6 或瘦素）。
这项荟萃分析纳入了 20 篇文献，涉及 18 项研究，共纳入 2921 例子宫内膜癌病例和 5302 例对照。14 篇文章报道了循环脂联素水平，7 篇报道了瘦素水平，3 篇报道了 TNFα 水平，3 篇报道了 IL-6 水平，1 篇报道了 IGF-I 水平。没有文章报道 IGF-II 的水平。与最低三分位组相比，循环脂联素水平最高三分位组的子宫内膜癌风险降低（汇总比值比[SOR] 0.51，95%置信区间[CI]：0.38-0.69，p<0.00001）。与最低三分位组相比，循环瘦素浓度最高三分位组的子宫内膜癌风险增加（SOR 2.19，95%CI：1.45-3.30，p=0.0002）。与最低三分位组相比，TNFα 和 IL-6 水平最高三分位组的癌症风险无差异（SOR 1.27，95%CI：0.88-1.83，p=0.20 和 SOR 1.20，95%CI：0.89-1.63，p=0.23）。
子宫内膜癌风险受脂联素和瘦素水平的影响呈负相关。TNFα 和 IL-6 与子宫内膜癌的总体风险之间似乎没有关系。
