难治性再生障碍性贫血：抗胸腺细胞球蛋白与大剂量皮质类固醇联合治疗

Refractory aplastic anemia: concomitant therapy with antithymocyte globulin and high-dose corticosteroids.

作者信息

Pulver K P, Flaum M A

出版信息

Am J Hematol. 1987 May;25(1):95-100. doi: 10.1002/ajh.2830250110.

Abstract

Bone marrow transplantation is possible for only a minority of patients with severe aplastic anemia. There has been successful treatment in some patients with immunosuppressive agents: high-dose 6-methylprednisolone, antilymphocyte globulin, and antithymocyte globulin. We report the successful treatment of two patients with severe aplastic anemia with the simultaneous administration of antithymocyte globulin and high-dose 6-methylprednisolone after failure with antithymocyte globulin and low-dose corticosteroids.

摘要

骨髓移植仅适用于少数重症再生障碍性贫血患者。一些患者使用免疫抑制剂治疗取得了成功：大剂量6-甲基强的松龙、抗淋巴细胞球蛋白和抗胸腺细胞球蛋白。我们报告了两名重症再生障碍性贫血患者在使用抗胸腺细胞球蛋白和小剂量皮质类固醇治疗失败后，同时给予抗胸腺细胞球蛋白和大剂量6-甲基强的松龙治疗成功的案例。