Department of Infectious Diseases, Renmin Hospital of Wuhan University, Wuhan, 430060, China.
Department of Infectious Diseases, Renmin Hospital of Wuhan University, Wuhan, 430060, China.
Eur J Pharmacol. 2022 Jan 15;915:174610. doi: 10.1016/j.ejphar.2021.174610. Epub 2021 Dec 21.
Acute liver failure (ALF) is a life-threatening disease and affects multiple organ systems. Pro-inflammatory factors derived from macrophage plays a key role in septicemia. Pinocembrin is a natural favonoid compound, which can be extracted from honey, propolis and several other plants. Recent investigations demonstrate that Pinocembrin has a variety of pharmacological activities, including anti-inflammatory and antioxidant. To investigate the effects of Pinocembrin on ALF, we explored its possible molecular mechanisms through the experiments in vivo and in vitro. Pre-treatment with Pinocembrin attenuated LPS-induced hepatocyte dysfunction and reduced levels of pro-inflammatory factors and macrophages infiltration. Pinocembrin inhibited the hepatocyte apoptosis and pro-inflammatory reaction of peritoneal macrophages by reducing reactive oxygen species (ROS) via the Sirt1/PPARα signaling pathway. Our study suggests that Pinocembrin might represent a novel therapeutic drug and offers a new method for the treatment of ALF.
急性肝衰竭（ALF）是一种危及生命的疾病，会影响多个器官系统。巨噬细胞来源的促炎因子在败血症中起关键作用。松属素是一种天然黄酮类化合物，可从蜂蜜、蜂胶和其他几种植物中提取。最近的研究表明，松属素具有多种药理活性，包括抗炎和抗氧化作用。为了研究松属素对 ALF 的影响，我们通过体内和体外实验探讨了其可能的分子机制。松属素预处理可减轻 LPS 诱导的肝细胞功能障碍，降低促炎因子水平和巨噬细胞浸润。松属素通过 Sirt1/PPARα 信号通路减少活性氧（ROS），抑制肝细胞凋亡和腹腔巨噬细胞的促炎反应。我们的研究表明，松属素可能代表一种新型治疗药物，为 ALF 的治疗提供了一种新方法。
