公众对∆-四氢大麻酚（δ-8-THC）的兴趣在美国各州限制∆-四氢大麻酚（δ-9-THC）使用后有所增加。
Public interest in ∆-Tetrahydrocannabinol (delta-8-THC) increased in US states that restricted ∆-Tetrahydrocannabinol (delta-9-THC) use.
机构信息
Herbert Wertheim School of Public Health and Human Longevity Science, University of California San Diego, La Jolla, CA, USA.
Division of Infectious Diseases and Global Public Health, Department of Medicine, University of California San Diego, La Jolla, CA, USA.
出版信息
Int J Drug Policy. 2022 Mar;101:103557. doi: 10.1016/j.drugpo.2021.103557. Epub 2021 Dec 21.
BACKGROUND
There is an expanding unregulated market for a psychotropic compound called ∆-Tetrahydrocannabinol (delta-8-THC) that is being derived from hemp, but there are no empirical estimates of public interest in this compound.
METHODS
To measure public interest, we obtained yearly Google query fractions (QFs) that mentioned delta-8-THC (i.e., "delta 8," "delta-8," or "Δ8") for the past decade (from January 2011 through August 2021) for every country and territory in the world and every state in the United States (US) from Google Trends. We also obtained the same trends for the last complete month of data for all US states (July 2021) to compare across cannabis use policies. We summarized QFs across years, countries, US states and cannabis policies in US states using linear regression, means and ratios. We estimated raw search counts for the US using comscore.com.
RESULTS
The global rate of delta-8-THC searches was stable between 2011 and 2019 before increasing by 257.0% from 2019 to 2020 and 705.0% from 2020 to 2021. In 2021, the rate of delta-8-THC searches in the US was at least 10 times higher than the rates in other countries or territories. In absolute terms, there were 22.3 million delta-8-THC searches in the US in the first 8 months of 2021 alone. Increases in delta-8-THC searches from 2020 to 2021 occurred in all 50 US states and the District of Columbia (Mean 854.2%; range = 256.4% - 2831.2%) but continued to vary substantially between states in 2021. In July 2021, the legal status of delta-9-THC use across US states explained 49.0% of the variance in delta-8-THC QFs between US states (R = 0.490; p < 0.001) and was inversely associated, where delta-8-THC QFs were higher in jurisdictions with stricter cannabis use policies.
CONCLUSION
Public interest in delta-8-THC increased rapidly in 2020 and 2021 and was particularly high in US states that restricted delta-9-THC use. Jurisdictions should clarify whether delta-8-THC can be sold as a hemp product.
背景
一种名为 ∆-四氢大麻酚（delta-8-THC）的精神药物化合物正在不受监管的市场上扩张，这种化合物是从大麻中提取的，但目前没有关于公众对此化合物兴趣的实证估计。
方法
为了衡量公众的兴趣，我们从谷歌趋势（Google Trends）获取了过去十年（2011 年 1 月至 2021 年 8 月）世界上每个国家和地区以及美国每个州的 delta-8-THC 每年谷歌查询分数（QF）。我们还获取了所有美国各州最后一个完整月（2021 年 7 月）的相同趋势，以便在大麻使用政策方面进行比较。我们使用线性回归、平均值和比率，总结了多年、国家、美国各州和美国各州大麻政策的 QF。我们使用 comscore.com 估算了美国的原始搜索次数。
结果
2011 年至 2019 年期间，delta-8-THC 的全球搜索率保持稳定，然后在 2019 年至 2020 年期间增长了 257.0%，2020 年至 2021 年期间增长了 705.0%。2021 年，美国 delta-8-THC 的搜索率至少是其他国家或地区的 10 倍。仅在 2021 年前 8 个月，美国就有 2230 万次 delta-8-THC 搜索。2020 年至 2021 年间，美国所有 50 个州和哥伦比亚特区（平均增长 854.2%；范围为 256.4%至 2831.2%）的 delta-8-THC 搜索量均有所增加，但 2021 年各州之间的差异仍很大。2021 年 7 月，美国各州 delta-9-THC 使用的法律地位解释了美国各州 delta-8-THC QF 之间 49.0%的差异（R=0.490；p<0.001），呈负相关，即 delta-8-THC QF 在限制 delta-9-THC 使用的司法管辖区较高。
结论
2020 年和 2021 年，公众对 delta-8-THC 的兴趣迅速增加，在美国限制 delta-9-THC 使用的州尤其高。各司法管辖区应明确 delta-8-THC 是否可以作为大麻产品销售。
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