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原发性不明的转移性空肠和回肠绒毛膜癌所致下消化道出血的腹腔镜和内镜超选治疗

Hypered laparoscopic and endoscopic management of lower gastrointestinal bleeding from metastatic Jejunal and ileal choriocarcinoma of unknown primary.

作者信息

Alshammery Sahar, Alghamdi Saeed, Alsherhi Mohammed, Alshahrani Amer

机构信息

King Abdullah bin Abdulaziz University Hospital, General Surgery Department Riyadh, Saudi Arabia.

General Surgery Department, Security Forces Hospital, Riyadh, Saudi Arabia.

出版信息

Int J Surg Case Rep. 2022 Jan;90:106636. doi: 10.1016/j.ijscr.2021.106636. Epub 2021 Dec 11.

Abstract

INTRODUCTION

Choriocarcinoma is form of malignant neoplasm that arise from trophoblastic cells that occurs mostly in ovaries and testes and it can metastasis to lungs, liver or to gastrointestinal tract.

PRESENTATION OF CASE

This is 37 years old female presented as a case of lower gi bleeding and was diagnosed to have metastatic jejunal and ilium choriocarcinoma of unknown primary and underwent ileocecal resection first then followed up with small bowel resection around 60 cm from duodenojejunal junction with primary anastomosis. The patient was found to have liver and brain metastasis and received chemotherapy with full response.

DISCUSSION

Choriocarcinoma is the most aggressive form of gestational trophoblastic disease that metastasizes through the lymphatic and hematogenous routes, and when its metastasis to the small bowel it's considered the worst prognosis with high mortality rate. Treatment consists of surgery and combined chemotherapy which is what our patient responded with.

CONCLUSION

Metastatic choriocarcinoma with unknown primary can be treated surgically with chemotherapy.

摘要

引言

绒毛膜癌是一种起源于滋养层细胞的恶性肿瘤,主要发生在卵巢和睾丸,可转移至肺、肝或胃肠道。

病例介绍

该37岁女性因下消化道出血就诊,被诊断为原发性不明的空肠和回肠转移性绒毛膜癌,首先接受了回盲部切除术,随后在距十二指肠空肠交界处约60厘米处进行了小肠切除术并进行了一期吻合。患者被发现有肝和脑转移,并接受化疗,反应良好。

讨论

绒毛膜癌是妊娠滋养细胞疾病中最具侵袭性的一种,通过淋巴和血行途径转移,当其转移至小肠时,预后最差,死亡率高。治疗包括手术和联合化疗,我们的患者正是如此治疗的。

结论

原发性不明的转移性绒毛膜癌可通过手术和化疗进行治疗。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d32d/8715062/4ea125e5ebc6/gr1.jpg

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