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肿瘤启动子十四烷酰佛波醇乙酸酯（TPA）可引发兔胸腺细胞亚细胞组分中锌的重新分布，这是通过X射线荧光测定的。

The tumor promoter tetradecanoyl-phorbol-acetate (TPA) elicits the redistribution of zinc in subcellular fractions of rabbit thymocytes measured by X-ray fluorescence.

作者信息

Csermely P, Gueth S, Somogyi J

出版信息

Biochem Biophys Res Commun. 1987 Apr 29;144(2):863-8. doi: 10.1016/s0006-291x(87)80044-x.

DOI:10.1016/s0006-291x(87)80044-x
PMID:3495267
Abstract

Prolonged (90 minutes) incubation with tumor promoter 12-O-tetradecanoyl-phorbol-13-acetate (TPA) elicits the redistribution of zinc from the nuclear fraction and mitochondria to the cytosol and microsomes in rabbit thymocytes. The zinc redistribution might play a role in the TPA-caused desensitization of T lymphocytes towards calcium and in the TPA-induced inhibition of Gl----S phase transition and cytotoxicity of T lymphocytes.

摘要

用肿瘤促进剂12 - O -十四烷酰佛波醇- 13 -乙酸酯（TPA）对兔胸腺细胞进行长达90分钟的孵育，会引发锌从细胞核部分和线粒体重新分布到细胞溶质和微粒体中。锌的重新分布可能在TPA导致的T淋巴细胞对钙脱敏以及TPA诱导的T淋巴细胞G1期向S期转变抑制和细胞毒性中发挥作用。

相似文献

1
The tumor promoter tetradecanoyl-phorbol-acetate (TPA) elicits the redistribution of zinc in subcellular fractions of rabbit thymocytes measured by X-ray fluorescence.肿瘤启动子十四烷酰佛波醇乙酸酯（TPA）可引发兔胸腺细胞亚细胞组分中锌的重新分布，这是通过X射线荧光测定的。
Biochem Biophys Res Commun. 1987 Apr 29;144(2):863-8. doi: 10.1016/s0006-291x(87)80044-x.
2
The tumor promoter tetradecanoylphorbol-13-acetate elicits the redistribution of heavy metals in subcellular fractions of rabbit thymocytes as measured by plasma emission spectroscopy.
Carcinogenesis. 1987 Nov;8(11):1663-6. doi: 10.1093/carcin/8.11.1663.
3
Zinc as a possible mediator of signal transduction in T lymphocytes.
Acta Physiol Hung. 1989;74(2):195-9.
4
Tumor promoter 12-0-tetradecanoyl-phorbol-13-acetate (TPA) can reduce the Ca-transporting ability of Ca-ionophores in T lymphocytes: the involvement of intracellular heavy metal ions.肿瘤促进剂十四烷酰佛波醇乙酯（TPA）可降低T淋巴细胞中钙离子载体的钙转运能力：细胞内重金属离子的作用。
J Cell Physiol. 1989 Mar;138(3):593-602. doi: 10.1002/jcp.1041380321.
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Effects of 12-O-tetradecanoyl phorbol-13-acetate (TPA) on rat thymocytes.
Scand J Immunol. 1989 Apr;29(4):485-8. doi: 10.1111/j.1365-3083.1989.tb01148.x.
6
12-O-Tetradecanoylphorbol-13-acetate enhances glycolysis in rat thymocytes.
Int J Biochem. 1985;17(7):847-50. doi: 10.1016/0020-711x(85)90276-9.
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Effect of tumor promoter 12-O-tetradecanoyl-phorbol 13-acetate on CD 7 expression by T lineage cells.肿瘤启动子12-O-十四烷酰佛波醇-13-乙酸酯对T淋巴细胞系细胞CD 7表达的影响。
Eur J Immunol. 1988 May;18(5):711-5. doi: 10.1002/eji.1830180509.
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Possible involvement of cyclophilin B and caspase-activated deoxyribonuclease in the induction of chromosomal DNA degradation in TCR-stimulated thymocytes.亲环蛋白B和半胱天冬酶激活的脱氧核糖核酸酶可能参与T细胞受体刺激的胸腺细胞中染色体DNA降解的诱导过程。
J Immunol. 2000 Oct 15;165(8):4281-9. doi: 10.4049/jimmunol.165.8.4281.
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Human T lymphocyte activation by tumor promoters: role of protein kinase C.肿瘤启动子对人T淋巴细胞的激活作用：蛋白激酶C的作用
J Immunol. 1987 May 15;138(10):3100-7.
10
12-O-tetradecanoylphorbol 13-acetate induces DNA cleavage at linker regions in mouse thymocytes.
J Biochem. 1989 May;105(5):673-5. doi: 10.1093/oxfordjournals.jbchem.a122724.

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Biochem J. 1994 Feb 15;298 ( Pt 1)(Pt 1):93-8. doi: 10.1042/bj2980093.