口腔鳞状细胞癌中人乳头瘤病毒感染的预后价值：一项荟萃分析。

The Prognostic Value of Human Papilloma Virus Infection in Oral Cavity Squamous Cell Carcinoma: A Meta-Analysis.

机构信息

Division of Oral and Maxillofacial Surgery, Faculty of Dentistry, The University of Hong Kong, Pok Fu Lam, Hong Kong.

出版信息

Laryngoscope. 2022 Sep;132(9):1760-1770. doi: 10.1002/lary.29996. Epub 2021 Dec 25.

Abstract

OBJECTIVES/HYPOTHESIS: Human papilloma virus (HPV) infection has been confirmed as a favorable prognostic factor in oropharyngeal cancer. However, the prognostic value of HPV in oral squamous cell carcinoma (OSCC) is still unclear. Therefore, a systematic review and meta-analysis was performed to evaluate the prognostic value of HPV infection in OSCC patients.

STUDY DESIGN

Systematic literature review with meta-analysis.

METHODS

A systematic literature review was conducted in accordance with PRISMA guidelines in PubMed, EMBASE, and MEDLINE databases. The primary outcomes were overall survival (OS), disease-free survival (DFS), disease-specific survival (DSS), and secondary outcomes were local control (LC), regional control (RC), and distant control (DC).

RESULTS

A total of 22 articles with 3065 OSCC patients were included in this study. Meta-analysis demonstrated that compared to HPV-negative OSCC patients, HPV-positive OSCC patients had a significantly shorter OS (hazard ratio [HR] = 1.45, 95% confidence intervals [CI], 1.10-1.93) and lower DC (HR = 2.16, 95% CI, 1.54-3.04). There was no significant difference in DFS (HR = 1.20, 95% CI, 0.63-2.26), DSS (HR = 1.20, 95% CI, 0.63-2.26), LC (HR = 1.44, 95% CI, 0.97-2.14), and RC (HR = 1.50, 95% CI, 0.98-2.30) between HPV-positive and negative OSCC patients. Sensitivity analysis confirmed the above results.

CONCLUSIONS

Our systematic review and meta-analysis reveal that HPV-positive is associated with significantly decreased OS and DC, suggesting HPV infection is an adverse prognostic factor in OSCC. Laryngoscope, 132:1760-1770, 2022.

摘要

目的/假设：人乳头瘤病毒（HPV）感染已被证实是口咽癌的有利预后因素。然而，HPV 在口腔鳞状细胞癌（OSCC）中的预后价值仍不清楚。因此，进行了系统评价和荟萃分析，以评估 HPV 感染在 OSCC 患者中的预后价值。

研究设计

系统文献回顾和荟萃分析。

方法

根据 PRISMA 指南，在 PubMed、EMBASE 和 MEDLINE 数据库中进行了系统文献检索。主要结局是总生存（OS）、无病生存（DFS）、疾病特异性生存（DSS），次要结局是局部控制（LC）、区域控制（RC）和远处控制（DC）。

结果

共纳入 22 篇文章，共 3065 例 OSCC 患者。荟萃分析表明，与 HPV 阴性 OSCC 患者相比，HPV 阳性 OSCC 患者的 OS 更短（风险比[HR]为 1.45，95%置信区间[CI]为 1.10-1.93），DC 更低（HR 为 2.16，95%CI 为 1.54-3.04）。DFS（HR 为 1.20，95%CI 为 0.63-2.26）、DSS（HR 为 1.20，95%CI 为 0.63-2.26）、LC（HR 为 1.44，95%CI 为 0.97-2.14）和 RC（HR 为 1.50，95%CI 为 0.98-2.30）在 HPV 阳性和阴性 OSCC 患者之间无显著差异。敏感性分析证实了上述结果。