Qin Yuxiao, Dong Xiaodan, Li Bo
Department of Oral Anatomy and Physiology, Jilin Provincial Key Laboratory of Oral Biomedical Engineering, Hospital of Stomatology, Jilin University, Changchun, China.
Front Cell Dev Biol. 2025 Jan 22;13:1531016. doi: 10.3389/fcell.2025.1531016. eCollection 2025.
Oral squamous cell carcinoma (OSCC) is the most common malignant tumour in the oral and maxillofacial region. Early diagnosis can significantly improve the 5-year survival rate of patients with OSCC. Therefore, it is extremely important to differentiate OSCC patients early, easily and quickly. Human saliva contains a variety of components that can be used as biomarkers for the diagnosis and prognosis of OSCC. Studies have shown that salivary microRNAs (miRNAs) and cytokines are closely associated with the progression of OSCC. The aim of this review is to summarize the research progress of salivary biomarkers (miRNAs and cytokines) in the past 3 years, and to explore the possibility of using miRNAs and cytokines to improve the diagnosis and prognosis of OSCC.
口腔鳞状细胞癌（OSCC）是口腔颌面部最常见的恶性肿瘤。早期诊断可显著提高OSCC患者的5年生存率。因此，尽早、轻松且快速地鉴别OSCC患者极为重要。人类唾液含有多种可作为OSCC诊断和预后生物标志物的成分。研究表明，唾液微小RNA（miRNA）和细胞因子与OSCC的进展密切相关。本综述的目的是总结过去3年唾液生物标志物（miRNA和细胞因子）的研究进展，并探讨使用miRNA和细胞因子改善OSCC诊断和预后的可能性。
