Woolf N
Postgrad Med J. 1978 Mar;54(629):156-62. doi: 10.1136/pgmj.54.629.156.
The presence of atherosclerotic lesions in young adults suggests that early stages of atherogenesis occur during childhood. The relationship of intimal lesions in childhood to fully developed atherosclerosis is briefly discussed. Factors likely to promote lipid accumulation within the arterial wall and proliferation of connective tissue elements are reviewed with particular emphasis on endothelial cell injury and the possible consequences of this for intimal smooth muscle cell proliferation.
年轻成年人中存在动脉粥样硬化病变表明动脉粥样硬化的早期阶段发生在儿童时期。本文简要讨论了儿童时期的内膜病变与完全发展的动脉粥样硬化之间的关系。对可能促进动脉壁内脂质积聚和结缔组织成分增殖的因素进行了综述，特别强调了内皮细胞损伤及其对内膜平滑肌细胞增殖可能产生的后果。
