Department of Dermatology and Venereology, Hospital de Santo António dos Capuchos, Centro Hospitalar e Universitário de Lisboa Central, Alameda de Santo António dos Capuchos, 1169-050 Lisboa, Portugal.
Consulta de Doenças Sexualmente Transmissíveis, Centro de Saúde da Lapa, R. de São Ciro 36, 1200-830 Lisboa Portugal.
Vaccine. 2022 Jan 21;40(2):275-281. doi: 10.1016/j.vaccine.2021.11.070. Epub 2021 Dec 23.
The quadrivalent human papillomavirus (HPV) vaccine was introduced in the Portuguese National Immunization Program in October 2008, targeting 13-year-old girls. This study aimed at evaluating the impact of HPV vaccination on the epidemiology of genital warts (GWs) in Portugal.
Observational, retrospective chart review study conducted at two free-of-charge walk-in sexually transmitted diseases (STD) clinics in Lisbon region. The medical records of all patients attending a first STD consultation at the study centers between May 2006 and December 2017 (observation period) were reviewed. The number of patients diagnosed with GWs and/or chlamydial infection at each year was documented and used to determine yearly prevalence of both conditions throughout the observation period. We broke down the observation period into pre-vaccination (May 2006 to December 2008) and vaccination (January 2009 to December 2017) periods.
Most patients were male (69.5%) and aged ≥ 25 years (78.1%). The majority of male patients were men who have sex with women (62.0%). Marked decreases in the prevalence of GWs between the last year of the pre-vaccination period (2008) and the last year of the observation period (2017) were found for female patients aged ≤ 19 and 20-24 years (86.8% and 77.4%, respectively). Lower decreases were observed for male patients of the same age groups (38.5% and 19.3%, respectively). GWs prevalence increased among patients ≥ 25 years (9.7% and 14.7% among female and male patients, respectively). Overall prevalence of chlamydial infection increased by 75.9% between 2008 and 2017.
This study contributes to the body of evidence showing that public HPV vaccination programs are effective in reducing the prevalence of GWs among vaccine-eligible patients. HPV vaccination program may significantly reduce the burden associated with GWs in Portugal.
四价人乳头瘤病毒（HPV）疫苗于 2008 年 10 月被引入葡萄牙国家免疫计划，针对 13 岁女孩。本研究旨在评估 HPV 疫苗接种对葡萄牙生殖器疣（GWs）流行病学的影响。
在里斯本地区的两个免费性病（STD）门诊进行了观察性、回顾性病历审查研究。在研究中心，对 2006 年 5 月至 2017 年 12 月（观察期）期间首次就诊 STD 的所有患者的医疗记录进行了回顾。记录了每年诊断为 GWs 和/或衣原体感染的患者人数，并用于确定整个观察期间这两种疾病的年度患病率。我们将观察期分为疫苗接种前（2006 年 5 月至 2008 年 12 月）和疫苗接种后（2009 年 1 月至 2017 年 12 月）两个时期。
大多数患者为男性（69.5%）和年龄≥25 岁（78.1%）。大多数男性患者为男男性接触者（62.0%）。在疫苗接种前最后一年（2008 年）和观察期最后一年（2017 年）之间，发现≤19 岁和 20-24 岁女性患者的 GWs 患病率显著下降（分别为 86.8%和 77.4%）。同一年龄组的男性患者的降幅较低（分别为 38.5%和 19.3%）。≥25 岁的患者 GWs 患病率增加（女性和男性患者分别为 9.7%和 14.7%）。总的衣原体感染患病率在 2008 年至 2017 年间增加了 75.9%。
本研究为表明公共 HPV 疫苗接种计划可有效降低疫苗可及人群中 GWs 患病率的证据提供了补充。HPV 疫苗接种计划可显著降低葡萄牙与 GWs 相关的负担。
