基于红细胞膜囊泡的仿生系统用于有效装载和释放姜黄素。
Inspiring biomimetic system based on red blood cell membrane vesicles for effective curcumin loading and release.
机构信息
Department of Materials Engineering, Isfahan University of Technology, Isfahan 84156-83111, Iran.
Department of Materials Engineering, Isfahan University of Technology, Isfahan 84156-83111, Iran.
出版信息
Int J Pharm. 2022 Feb 5;613:121419. doi: 10.1016/j.ijpharm.2021.121419. Epub 2021 Dec 22.
The aim of this study is to introduce an inspiring biomimetic system based on the red blood cell membrane (RBCM) vesicles for improved encapsulation efficiency and release of curcumin (Cur). Here, the role of the sonication time (0.5, 1.5, 3 and 5 min) on the properties of RBCM-CUR vesicles is investigated. It is determined that the hydrodynamic vesicle size, zeta potential, and release behavior are tunable by changing the sonication time. Noticeably, the average size of vesicles decreased from 163.0 ± 21 nm to 116.3 ± 16 nm by increasing the sonication time from 0.5 to 5 min. Moreover, the drug release value, after 24 h incubation, enhances from 57 to 99% with the expansion of sonication from 0.5 to 5 min. Additionally, the entrapment efficiency of Cur as a model drug is high in whole sonication time, owing to the amphiphilic nature of RBCM. Finally, the RBCM-CUR vesicles are not only cytocompatible, but also could support the attachment and proliferation of fibroblast cells in vitro. The RBCM based system for delivery of Cur could be a promising system for the wound healing applications.
本研究旨在介绍一种基于红细胞膜（RBCM）囊泡的仿生系统，以提高姜黄素（Cur）的包封效率和释放率。在此，研究了超声时间（0.5、1.5、3 和 5 分钟）对 RBCM-CUR 囊泡性质的影响。结果表明，通过改变超声时间可以调节囊泡的流体力学粒径、zeta 电位和释放行为。值得注意的是，随着超声时间从 0.5 分钟增加到 5 分钟，囊泡的平均粒径从 163.0±21nm 减小到 116.3±16nm。此外，随着超声时间从 0.5 分钟扩展到 5 分钟，24 小时孵育后的药物释放值从 57%提高到 99%。此外，由于 RBCM 的两亲性，Cur 作为模型药物的包封效率在整个超声时间内都很高。最后，RBCM 基递送系统对于 Cur 的递送可能是一种有前途的用于伤口愈合应用的系统。
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