Barthó L, Lembeck F, Holzer P
Eur J Pharmacol. 1987 Mar 31;135(3):449-51. doi: 10.1016/0014-2999(87)90699-6.
The motor effects of calcitonin gene-related peptide (CGRP) on the guinea-pig ileum (GPI) longitudinal muscle were investigated. CGRP (0.1-100 nM) concentration dependently relaxed ilea precontracted with histamine and inhibited electrically induced cholinergic contractions. At higher concentrations (3-100 nM) CGRP also caused a slight contraction of non-stimulated ilea. Further pharmacological analysis of the CGRP-induced relaxation which seems to be the primary CGRP effect in the GPI, indicated that the effect was due to a direct action on the longitudinal muscle.
研究了降钙素基因相关肽（CGRP）对豚鼠回肠（GPI）纵肌的运动效应。CGRP（0.1 - 100 nM）浓度依赖性地舒张由组胺预收缩的回肠，并抑制电诱导的胆碱能收缩。在较高浓度（3 - 100 nM）时，CGRP也会引起未受刺激回肠的轻微收缩。对CGRP诱导的舒张作用（这似乎是CGRP在GPI中的主要作用）进行的进一步药理学分析表明，该作用是由于对纵肌的直接作用。
