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PD-L1:它能否成为宫颈癌预后的生物标志物或有前途的治疗靶点?

PD-L1: Can it be a biomarker for the prognosis or a promising therapeutic target in cervical cancer?

机构信息

Department of Gynecology, NO. 1 Teaching Hospital, China Medical University, Shenyang 110001, China.

Department of Gynecology, NO. 1 Teaching Hospital, China Medical University, Shenyang 110001, China.

出版信息

Int Immunopharmacol. 2022 Feb;103:108484. doi: 10.1016/j.intimp.2021.108484. Epub 2021 Dec 23.

Abstract

Cervical cancer is one of the most common in the female genital tract and remains a leading cause that threatens the health and lives of women worldwide, although preventive vaccines and early diagnosis have reduced mortality. While treatment by operation and chemoradiotherapy for early-stage patients achieve good outcomes, the great majority of cervical cancers caused by the human papilloma virus (HPV) make immunotherapy realizable for patients with advanced and recurrent cervical cancer. To date, some clinical trials of checkpoint immunotherapy in cervical cancer have indicated significant benefits of programmed cell death-1/programmed cell death-ligand 1 (PD-1/PD-L1) inhibitors, providing strong evidence for PD-1/PD-L1 as a therapeutic target. In this review article, we discuss the role of PD-L1 and the application of PD-L1 inhibitors in cervical cancer, with the aim of providing direction for future research.

摘要

宫颈癌是女性生殖道最常见的恶性肿瘤之一,尽管预防性疫苗和早期诊断已经降低了死亡率,但它仍然是威胁全球女性健康和生命的主要原因之一。对于早期患者,手术和放化疗治疗效果良好,但大多数由人乳头瘤病毒(HPV)引起的宫颈癌为免疫治疗提供了可能,为晚期和复发性宫颈癌患者带来了希望。迄今为止,一些宫颈癌的检查点免疫治疗的临床试验表明,程序性细胞死亡蛋白-1/程序性细胞死亡配体 1(PD-1/PD-L1)抑制剂具有显著的疗效,为 PD-1/PD-L1 作为治疗靶点提供了有力的证据。在这篇综述文章中,我们讨论了 PD-L1 的作用以及 PD-L1 抑制剂在宫颈癌中的应用,旨在为未来的研究提供方向。

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