代谢在辅助性T细胞17分化及自身免疫性疾病中的作用。
The role of metabolism in Th17 cell differentiation and autoimmune diseases.
作者信息
Wang Guang, Su Zehong, Li Hui, Xiao Li, Li Chengyue, Lian Gaojian
机构信息
Department of Biochemistry and Molecular Biology, Hengyang Medical College, University of South China, Hengyang, Hunan 421001, China.
Department of Biochemistry and Molecular Biology, Hengyang Medical College, University of South China, Hengyang, Hunan 421001, China; Key Laboratory of Ecological Environment and Critical Human Diseases Prevention of Hunan Province Department of Education.
出版信息
Int Immunopharmacol. 2022 Feb;103:108450. doi: 10.1016/j.intimp.2021.108450. Epub 2021 Dec 23.
T helper 17 cells (Th17) have been associated with the pathogenesis of autoimmune and inflammatory diseases, which makes them become a sharp focus when the researchers are seeking therapeutic target for these diseases. A growing body of evidence has suggested that cellular metabolism dictates Th17 cell differentiation and effector function. Moreover, various studies have disclosed that metabolism is linked to the occurrence of autoimmune diseases. In this article, we reviewed the most recent findings regarding the importance of metabolism in Th17 cell differentiation and autoimmune diseases and also discussed the modulation mechanisms of glycolysis, fatty acid and cholesterol synthesis, and amino acids metabolism for Th17 cell differentiation. This review summarized the potential therapeutic or preventing strategies for Th17 cell-mediated autoimmune diseases.
辅助性T细胞17（Th17）与自身免疫性疾病和炎症性疾病的发病机制相关，这使得它们在研究人员寻找这些疾病的治疗靶点时成为一个焦点。越来越多的证据表明，细胞代谢决定了Th17细胞的分化和效应功能。此外，各种研究已经揭示代谢与自身免疫性疾病的发生有关。在本文中，我们综述了关于代谢在Th17细胞分化和自身免疫性疾病中的重要性的最新发现，并讨论了糖酵解、脂肪酸和胆固醇合成以及氨基酸代谢对Th17细胞分化的调节机制。本综述总结了针对Th17细胞介导的自身免疫性疾病的潜在治疗或预防策略。
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