Zhang Meng-Jie, Wen Yan, Sun Zhi-Jun
State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, School & Hospital of Stomatology, Frontier Science Center for Immunology and Metabolism, Taikang Center for Life and Medical Sciences, Wuhan University, Wuhan, 430079, China.
Department of Oral Maxillofacial-Head Neck Oncology, School & Hospital of Stomatology, Wuhan University, Wuhan, 430079, China.
BMC Med. 2025 Apr 14;23(1):217. doi: 10.1186/s12916-025-04037-7.
Cancer immunotherapy has achieved unprecedented success in the field of cancer therapy. However, its potential is constrained by a low therapeutic response rate.
Tertiary lymphoid structure (TLS) plays a crucial role in antitumor immunity and is associated with a good prognosis. Metabolic reprogramming, as a hallmark of the tumor microenvironment, can influence tumor immunity and promote the formation of follicular helper T cells and germinal centers. However, many current studies focus on the correlation between metabolism and TLS formation factors, and there is insufficient direct evidence to suggest that metabolism drives TLS formation. This review provided a comprehensive summary of the relationship between metabolism and TLS formation, highlighting glucose metabolism, lipid metabolism, amino acid metabolism, and vitamin metabolism.
In the future, an in-depth exploration of how metabolism affects cell interactions and the role of microorganisms in TLS will significantly advance our understanding of metabolism-enhanced antitumor immunity.
癌症免疫疗法在癌症治疗领域取得了前所未有的成功。然而，其潜力受到低治疗反应率的限制。
三级淋巴结构（TLS）在抗肿瘤免疫中起关键作用，并与良好的预后相关。代谢重编程作为肿瘤微环境的一个标志，可以影响肿瘤免疫并促进滤泡辅助性T细胞和生发中心的形成。然而，目前许多研究集中在代谢与TLS形成因子之间的相关性上，并且没有足够的直接证据表明代谢驱动TLS形成。本综述全面总结了代谢与TLS形成之间的关系，重点介绍了葡萄糖代谢、脂质代谢、氨基酸代谢和维生素代谢。
未来，深入探索代谢如何影响细胞相互作用以及微生物在TLS中的作用，将显著推进我们对代谢增强抗肿瘤免疫的理解。
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