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Parathyroid hormone regulates phosphate transport in OK cells via an irreversible inactivation of a membrane protein.

作者信息

Malmström K, Murer H

出版信息

FEBS Lett. 1987 Jun 1;216(2):257-60. doi: 10.1016/0014-5793(87)80701-9.

DOI:10.1016/0014-5793(87)80701-9
PMID:3495458
Abstract

In a cultured, renal epithelial cell line, OK, parathyroid hormone (PTH) reduces Na/phosphate cotransport and upon removal of the hormone the activity is regained. Cycloheximide, an inhibitor of protein synthesis, did not interfere with the PTH action, but prevented the reduced phosphate transport from regaining its original activity. Drugs, such as colchicine, that disrupt the microtubular network, lessened both the action of PTH and prevented the recovery of activity. The results are consistent with irreversible inactivation of a plasma membrane protein necessary for full activity of the Na/phosphate cotransport.

摘要

相似文献

1
Parathyroid hormone regulates phosphate transport in OK cells via an irreversible inactivation of a membrane protein.
FEBS Lett. 1987 Jun 1;216(2):257-60. doi: 10.1016/0014-5793(87)80701-9.
2
Parathyroid hormone inhibits plasma membrane Pi transport without changing endocytic activity in opossum kidney cells.甲状旁腺激素抑制负鼠肾细胞的质膜磷转运，而不改变其胞吞活性。
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Transfection-mediated expression of a dominant cAMP-resistant phenotype in the opossum kidney (OK) cell line prevents parathyroid hormone-induced inhibition of Na-phosphate cotransport. A protein kinase-A-mediated event.转染介导的负显性环磷酸腺苷（cAMP）抗性表型在负鼠肾（OK）细胞系中的表达可防止甲状旁腺激素诱导的钠-磷酸盐共转运抑制。这是一种蛋白激酶A介导的事件。
J Clin Invest. 1990 Nov;86(5):1442-50. doi: 10.1172/JCI114860.
4
Regulation of sodium-dependent phosphate transport by parathyroid hormone in opossum kidney cells: adenosine 3',5'-monophosphate-dependent and -independent mechanisms.负鼠肾细胞中甲状旁腺激素对钠依赖性磷酸盐转运的调节：3',5'-环磷酸腺苷依赖性和非依赖性机制
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5
Parathyroid hormone action on phosphate transport is inhibited by high osmolality.高渗状态会抑制甲状旁腺激素对磷酸盐转运的作用。
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6
Role of microtubules in the adaptive response to low phosphate of Na/Pi cotransport in opossum kidney cells.微管在负鼠肾细胞中钠/磷酸盐共转运对低磷酸盐适应性反应中的作用。
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7
Parathyroid hormone inhibition of Na+/phosphate cotransport in OK cells: generation of second messengers in the regulatory cascade.甲状旁腺激素对OK细胞中钠/磷酸盐协同转运的抑制作用：调节级联反应中第二信使的产生。
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8
Intracellular cascades in the parathyroid-hormone-dependent regulation of Na+/phosphate cotransport in OK cells.甲状旁腺激素依赖性调节OK细胞中钠/磷酸盐协同转运的细胞内信号级联反应。
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Parathyroid hormone inhibits phosphate transport in OK cells but not in LLC-PK1 and JTC-12.P3 cells.甲状旁腺激素抑制OK细胞中的磷酸盐转运，但不抑制LLC-PK1和JTC-12.P3细胞中的磷酸盐转运。
Am J Physiol. 1986 Jul;251(1 Pt 1):C23-31. doi: 10.1152/ajpcell.1986.251.1.C23.
10
Endocytosis and phosphate transport in OK epithelial cells.OK上皮细胞中的内吞作用和磷酸盐转运
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引用本文的文献

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2
In vivo evidence for an interplay of FGF23/Klotho/PTH axis on the phosphate handling in renal proximal tubules.体内证据表明 FGF23/klotho/PTH 轴在肾脏近端小管的磷酸盐处理中相互作用。
Am J Physiol Renal Physiol. 2018 Nov 1;315(5):F1261-F1270. doi: 10.1152/ajprenal.00650.2017. Epub 2018 Jul 11.
3
Effects of dietary Pi on the renal Na+-dependent Pi transporter NaPi-2 in thyroparathyroidectomized rats.
饮食中磷对甲状旁腺切除大鼠肾脏钠依赖性磷转运体NaPi-2的影响。
Biochem J. 1998 Jul 1;333 ( Pt 1)(Pt 1):175-81. doi: 10.1042/bj3330175.
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Parathyroid hormone leads to the lysosomal degradation of the renal type II Na/Pi cotransporter.甲状旁腺激素导致肾II型钠/磷协同转运蛋白的溶酶体降解。
Proc Natl Acad Sci U S A. 1998 Feb 17;95(4):1909-14. doi: 10.1073/pnas.95.4.1909.
5
Role of microtubules in the adaptive response to low phosphate of Na/Pi cotransport in opossum kidney cells.微管在负鼠肾细胞中钠/磷酸盐共转运对低磷酸盐适应性反应中的作用。
Pflugers Arch. 1993 Feb;422(5):516-22. doi: 10.1007/BF00375080.
6
Intracellular cascades in the parathyroid-hormone-dependent regulation of Na+/phosphate cotransport in OK cells.甲状旁腺激素依赖性调节OK细胞中钠/磷酸盐协同转运的细胞内信号级联反应。
Biochem J. 1988 Apr 1;251(1):207-13. doi: 10.1042/bj2510207.
7
Flow cytometric analysis of intracellular pH in cultured opossum kidney (OK) cells.培养的负鼠肾（OK）细胞内pH值的流式细胞术分析。
J Membr Biol. 1989 Apr;108(1):31-43. doi: 10.1007/BF01870423.
8
Regulation of Na+/H+ exchange in opossum kidney cells by parathyroid hormone, cyclic AMP and phorbol esters.甲状旁腺激素、环磷酸腺苷和佛波酯对负鼠肾细胞中Na+/H+交换的调节
Pflugers Arch. 1990 Jan;415(4):461-70. doi: 10.1007/BF00373624.