Department of Laboratory Medicine, AZ St-Jan Hospital, Brugge, Belgium.
Department of Diagnostic Sciences, Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium.
Biochem Med (Zagreb). 2022 Feb 15;32(1):010704. doi: 10.11613/BM.2022.010704. Epub 2021 Dec 15.
Two new formulas, the Martin-Hopkins and the Sampson formula, were recently developed to overcome shortcomings of the Friedewald formula for calculating LDL-cholesterol. We aimed to compare the concordance of the two formulas with apolipoprotein B (apoB), a surrogate marker of the number of LDL particles.
In a study of serum lipid data of 1179 patients who consulted the AZ St-Jan Hospital Bruges for cardiovascular risk assessment, the correlation and concordance of the Friedewald, Martin-Hopkins and Sampson formulas with apoB concentration, measured by immunonephelometry, were determined and compared.
The Martin-Hopkins formula showed significantly higher correlation coefficient than the Friedewald formula with apoB in the entire dataset and in patients with low LDL-cholesterol < 1.8 mmol/L. Both Martin-Hopkins and Sampson formulas yielded > 70% concordance of LDL-cholesterol with regard to treatment group classification based on population-equivalent thresholds of apoB in hypertriglyceridemic patients (2-4.5 mmol/L), with the highest concordance (75.6%) obtained using Martin-Hopkins formula . 60.5% with Friedewald formula.
The Martin-Hopkins (and, to a lesser extent, Sampson) formula is more closely associated with the number of LDL particles than Friedewald formula. This, in combination with literature evidence of lesser accuracy of the Friedewald formula, is an argument to switch from Friedewald to a modified, improved formula.
为了克服 Friedewald 公式在计算 LDL 胆固醇方面的缺陷，最近开发了两种新的公式，即 Martin-Hopkins 公式和 Sampson 公式。我们旨在比较这两种公式与载脂蛋白 B（apoB）的一致性，apoB 是 LDL 颗粒数的替代标志物。
在对 1179 名因心血管风险评估而到布鲁日 AZ St-Jan 医院就诊的患者的血清脂质数据进行的一项研究中，通过免疫比浊法测定 apoB 浓度，确定并比较了 Friedewald、Martin-Hopkins 和 Sampson 公式与 apoB 浓度的相关性和一致性。
Martin-Hopkins 公式与整个数据集和 LDL 胆固醇 < 1.8 mmol/L 的低 LDL 胆固醇患者的 apoB 相关性显著高于 Friedewald 公式。在患有高甘油三酯血症（2-4.5 mmol/L）的患者中，基于 apoB 的人群等效阈值将 LDL 胆固醇治疗组分类，Martin-Hopkins 和 Sampson 公式均产生 > 70%的 LDL 胆固醇一致性，Martin-Hopkins 公式的一致性最高（75.6%），Friedewald 公式为 60.5%。
与 Friedewald 公式相比，Martin-Hopkins（以及在较小程度上，Sampson）公式与 LDL 颗粒数的相关性更强。这与 Friedewald 公式准确性较差的文献证据相结合，是从 Friedewald 公式切换到改进的改良公式的一个论据。
