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使用病毒跨神经元示踪剂构建从大脑皮层到内脏的连接组。

The connectome from the cerebral cortex to the viscera using viral transneuronal tracers.

作者信息

Li Zhixiao, Li Zhen, Xu Weiguo, Li Yujuan, Wang Qian, Xu Hui, Manyande Anne, Wu Duozhi, Feng Maohui, Xiang Hongbing

机构信息

Department of Anesthesiology and Pain Medicine, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology Wuhan 430030, Hubei, China.

Department of Orthopedics, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology Wuhan 430030, China.

出版信息

Am J Transl Res. 2021 Nov 15;13(11):12152-12167. eCollection 2021.

Abstract

As an emerging framework in neuroscience, brain connectomics is well suited for investigating key questions on brain complexity by combining viral transneuronal tracing and whole brain graphic methodologies using analytical tools of network science. Transsynaptic viral tract-tracing in the toolbox of neural labeling methods has been a significant development in the connectomics field to decipher the circuit-level architecture of the cerebral cortex. In the present work, we reviewed the current methods enabling structural connectivity from the viscera to the cerebral cortex mapping with viral transneuronal tracers and showed how such neuroanatomic connectomic data could be used to infer new structural and functional information in viscera-cerebral cortex circuits.

摘要

作为神经科学中的一个新兴框架,脑连接组学非常适合通过结合病毒跨神经元追踪和使用网络科学分析工具的全脑图形方法来研究有关脑复杂性的关键问题。神经标记方法工具箱中的跨突触病毒束追踪是连接组学领域的一项重大进展,用于破译大脑皮层的电路级结构。在本研究中,我们回顾了当前使用病毒跨神经元示踪剂实现从内脏到大脑皮层映射的结构连接的方法,并展示了如何利用这些神经解剖连接组学数据推断内脏-大脑皮层回路中的新结构和功能信息。

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