Huang Yan, He Zhigang, Manyande Anne, Feng Maohui, Xiang Hongbing
Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
Department of Interventional Therapy, the First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, China.
Front Bioeng Biotechnol. 2022 Aug 16;10:966138. doi: 10.3389/fbioe.2022.966138. eCollection 2022.
The technique of organ transplantation is well established and after transplantation the patient might be faced with the problem of nerve regeneration of the transplanted organ. Transplanted organs are innervated by the sympathetic, parasympathetic, and visceral sensory plexuses, but there is a lack of clarity regarding the neural influences on the heart, liver and kidneys and the mechanisms of their innervation. Although there has been considerable recent work exploring the potential mechanisms of nerve regeneration in organ transplantation, there remains much that is unknown about the heterogeneity and individual variability in the reinnervation of organ transplantation. The widespread availability of radioactive nerve tracers has also made a significant contribution to organ transplantation and has helped to investigate nerve recovery after transplantation, as well as providing a direction for future organ transplantation research. In this review we focused on neural tracer imaging techniques in humans and provide some conceptual insights into theories that can effectively support our choice of radionuclide tracers. This also facilitates the development of nuclear medicine techniques and promotes the development of modern medical technologies and computer tools. We described the knowledge of neural regeneration after heart transplantation, liver transplantation and kidney transplantation and apply them to various imaging techniques to quantify the uptake of radionuclide tracers to assess the prognosis of organ transplantation. We noted that the aim of this review is both to provide clinicians and nuclear medicine researchers with theories and insights into nerve regeneration in organ transplantation and to advance imaging techniques and radiotracers as a major step forward in clinical research. Moreover, we aimed to further promote the clinical and research applications of imaging techniques and provide clinicians and research technology developers with the theory and knowledge of the nerve.
器官移植技术已经成熟，移植后患者可能面临移植器官神经再生的问题。移植器官由交感神经、副交感神经和内脏感觉神经丛支配，但关于神经对心脏、肝脏和肾脏的影响及其支配机制仍不明确。尽管最近有大量工作探索器官移植中神经再生的潜在机制，但关于器官移植再支配的异质性和个体变异性仍有许多未知之处。放射性神经示踪剂的广泛应用也为器官移植做出了重大贡献，有助于研究移植后的神经恢复情况，并为未来器官移植研究提供方向。在本综述中，我们重点关注人类神经示踪成像技术，并对能够有效支持我们选择放射性核素示踪剂的理论提供一些概念性见解。这也有助于核医学技术的发展，促进现代医学技术和计算机工具的发展。我们描述了心脏移植、肝脏移植和肾脏移植后神经再生的知识，并将其应用于各种成像技术，以量化放射性核素示踪剂的摄取，评估器官移植的预后。我们指出，本综述的目的既是为临床医生和核医学研究人员提供器官移植中神经再生的理论和见解，也是将成像技术和放射性示踪剂作为临床研究向前迈出的重要一步。此外，我们旨在进一步促进成像技术的临床和研究应用，并为临床医生和研究技术开发者提供神经方面的理论和知识。
