环吡咯酮衍生物佐匹克隆的行为学及脑电图效应

Behavioral and electroencephalographic effects of zopiclone, a cyclopyrrolone derivative.

作者信息

Ueki S, Watanabe S, Yamamoto T, Kataoka Y, Shibata S, Shibata K, Ohta H, Shimazoe T, Kawamoto H

出版信息

Jpn J Pharmacol. 1987 Mar;43(3):309-26. doi: 10.1254/jjp.43.309.

DOI:10.1254/jjp.43.309

Abstract

Behavioral effects of zopiclone were investigated in mice and rats and compared with the data on diazepam, nitrazepam and flurazepam. The electroencephalographic effect of the drug was also examined in unanesthetized rabbits with chronic electrode implants and compared with that of diazepam. The present results indicate that zopiclone possesses pharmacological properties qualitatively similar to benzodiazepines, which are characterized by potent anticonflict and antiaggressive effects and much weaker anticonvulsant, muscle relaxant, ataxiogenic, sedative and anesthesia potentiating effects; the properties of this drug were compared with those of diazepam, nitrazepam and flurazepam. Zopiclone suppressed the EEG arousal responses and inhibited afterdischarges induced by electrical stimulation of the hippocampus and amygdala. The effects of zopiclone on EEG and afterdischarges were approximately 1/10 those of diazepam.

摘要

在小鼠和大鼠身上研究了佐匹克隆的行为效应，并与地西泮、硝西泮和氟西泮的数据进行了比较。还在植入慢性电极的未麻醉兔身上检查了该药物的脑电图效应，并与地西泮的效应进行了比较。目前的结果表明，佐匹克隆具有与苯二氮䓬类药物在性质上相似的药理特性，其特点是具有强大的抗冲突和抗攻击作用，而抗惊厥、肌肉松弛、致共济失调、镇静和麻醉增强作用则弱得多；将该药物的特性与地西泮、硝西泮和氟西泮的特性进行了比较。佐匹克隆抑制了脑电图的觉醒反应，并抑制了由海马体和杏仁核电刺激诱导的后放电。佐匹克隆对脑电图和后放电的作用约为地西泮的1/10。