Human alpha lymphotoxin (LT): studies examining the mechanism(s) of LT-induced inflammation and tumor destruction in vivo.

Recent information from our laboratories indicates that human alpha lymphotoxin (LT) is a powerful mediator of tumor necrosis, and inflammation. Our studies indicate that LT induced effects in vivo are complex and involve multiple mechanisms(s). The data presented here suggests that LT induced tissue destructive and inflammatory reactions mediated by cytolytic and antigen reactive lymphocytes may have a role in a much broader variety of inflammatory processes than had been appreciated.