Department of Mechanical and Aerospace Engineering, Politecnico di Torino, 10129 Torino, Italy.
Department of Environmental, Land and Infrastructure Engineering, Politecnico di Torino, 10129 Torino, Italy.
Rev Cardiovasc Med. 2021 Dec 22;22(4):1461-1469. doi: 10.31083/j.rcm2204150.
Computational hemodynamics is becoming an increasingly important tool in clinical applications and surgical procedures involving the cardiovascular system. Aim of this review is to provide a compact summary of state of the art 0D-1D multiscale models of the arterial coronary system, with particular attention to applications related to cardiac arrhythmias, whose effects on the coronary circulation remain so far poorly understood. The focus on 0D-1D models only is motivated by the competitive computational cost, the reliability of the outcomes for the whole cardiovascular system, and the ability to directly account for cardiac arrhythmias. The analyzed studies show that cardiac arrhythmias by their own are able to promote significant alterations of the coronary hemodynamics, with a worse scenario as the mean heart rate (HR) increases. The present review can stimulate future investigation, both in computational and clinical research, devoted to the hemodynamic effects induced by cardiac arrhythmias on the coronary circulation.
计算血液动力学在涉及心血管系统的临床应用和手术中正成为一种越来越重要的工具。本文旨在对动脉冠状动脉系统的最新 0D-1D 多尺度模型进行简要总结，特别关注与心律失常相关的应用，目前心律失常对冠状动脉循环的影响仍知之甚少。之所以将重点放在 0D-1D 模型上，是因为它们具有竞争的计算成本、对整个心血管系统结果的可靠性，以及能够直接解释心律失常的能力。分析表明，心律失常本身能够促进冠状动脉血液动力学的显著变化，随着平均心率（HR）的增加，情况会变得更糟。本综述可以激发未来在计算和临床研究方面的进一步研究，致力于心律失常对冠状动脉循环产生的血液动力学影响。
