Caring Futures Institute, College of Nursing and Health Sciences, Flinders University, Bedford Park, SA 5042, Australia.
College of Medicine and Public Health, Flinders University, Bedford Park, SA 5042, Australia.
Nutrients. 2021 Dec 20;13(12):4557. doi: 10.3390/nu13124557.
Dietary intake, specifically consumption of anti-inflammatory micronutrients, can play a role in both cancer initiation as well as the treatment-related outcomes experienced by patients receiving systemic cancer therapy. Increasing research is being conducted to determine whether micronutrient supplementation can aid in altering the tumor microenvironment (TME), reducing inflammatory side effects and immune-related adverse events (irAEs). However, further research pertaining to the adequacy of dietary micronutrient intake is indicated in the oncology cohort. Currently, no tool measuring dietary intakes of various micronutrients exists in the oncology population. In this study, a 21-item food frequency questionnaire (FFQ) measuring intakes of 14 different micronutrients was validated using diet history as the reference method in 112 oncology patients. Bland Altman plot and Passing Bablok regression analysis were conducted to determine agreement between the two methods. The results showed adequate agreement between FFQ and diet history for 12 nutrients including copper, iron, vitamins A, E, and D, alpha linolenic acid (ALA), long-chain omega 3 fatty acids (LC n3-FA), arginine, glutamic acid, isoleucine, leucine, and valine. This 21-item FFQ, which takes an average of 10 min to complete, can be utilized as a quick screening tool to determine adequacy for 12 different micronutrients in place of a diet history.
饮食摄入，特别是抗炎微量营养素的消耗，可能在癌症的发生以及接受全身性癌症治疗的患者的治疗相关结果中发挥作用。越来越多的研究正在进行，以确定微量营养素补充是否有助于改变肿瘤微环境（TME），减少炎症副作用和免疫相关不良事件（irAEs）。然而，在肿瘤学队列中，需要进一步研究饮食微量营养素摄入的充足性。目前，肿瘤人群中不存在测量各种微量营养素饮食摄入量的工具。在这项研究中，使用饮食史作为参考方法，在 112 名肿瘤患者中验证了一种包含 14 种不同微量营养素的 21 项食物频率问卷（FFQ）。采用 Bland-Altman 图和 Passing-Bablok 回归分析来确定两种方法之间的一致性。结果表明，FFQ 与饮食史在 12 种营养素方面具有足够的一致性，包括铜、铁、维生素 A、E 和 D、α-亚麻酸（ALA）、长链 ω-3 脂肪酸（LC n3-FA）、精氨酸、谷氨酸、异亮氨酸、亮氨酸和缬氨酸。这种 21 项的 FFQ 平均需要 10 分钟完成，可以作为一种快速筛选工具，以确定 12 种不同微量营养素的充足性，代替饮食史。
