Department of Otorhinolaryngology-Head and Neck Surgery, Osaka Medical and Pharmaceutical University, Takatsuki, Japan.
Ear Nose Throat J. 2024 Aug;103(8):497-503. doi: 10.1177/01455613211064013. Epub 2021 Dec 28.
Parotid tumors are rare neoplasms in adults but are exceedingly infrequent in adolescents. We aimed to determine the clinical characteristics and outcomes of parotid tumors in adolescents under 20 years old.
Between 1999 and 2020, 979 cases of benign parotid tumors and 236 cases of malignant parotid tumors were treated surgically in our department. Of these, 12 benign cases (1.2%) and 9 malignant cases (3.8%) were in adolescents. There were no benign or malignant cases for those aged under 10 years.
Regarding the histological type, all benign tumors were pleomorphic adenomas. About half of malignant tumors were mucoepidermoid carcinomas, and excluding one high-grade case, the grade of malignancy was all low/intermediate. The accuracy of fine-needle aspiration cytology among adolescents showed no significant difference with that of adults. In contrast to adults, adolescent benign tumor cases showed a markedly high rate of pleomorphic adenomas and no postoperative facial nerve palsy. Malignant tumors in adolescents had a different trend than adults; low/intermediate-grade malignancies were common and thus few symptoms/signs of malignancy could be observed. As well, the accuracy of fine-needle aspiration cytology was poor. All cases had a good prognosis and are disease-free survival.
Parotid tumors in adolescents are rare but have several characteristics that are distinct from adults. As long-term observation is required posttreatment in adolescent patients, recurrence in benign pleomorphic adenomas and poor long-term prognosis in malignant tumors, especially for those with low/intermediate-grade malignancy, are more likely to be observed.
成人腮腺肿瘤少见，但青少年中极为罕见。本研究旨在明确 20 岁以下青少年腮腺肿瘤的临床特征和结局。
1999 年至 2020 年，本科共手术治疗 979 例腮腺良性肿瘤和 236 例腮腺恶性肿瘤，其中良性肿瘤 12 例（1.2%），恶性肿瘤 9 例（3.8%），10 岁以下均无良性或恶性肿瘤。
组织学类型方面，所有良性肿瘤均为多形性腺瘤。约一半恶性肿瘤为黏液表皮样癌，除 1 例高级别外，其余均为低/中级别。青少年细针穿刺细胞学的准确率与成人相比无显著差异。与成人不同，青少年良性肿瘤以多形性腺瘤为主，且无术后面神经瘫痪。青少年恶性肿瘤与成人不同，中低级别恶性肿瘤常见，因此很少有恶性肿瘤的症状/体征，细针穿刺细胞学准确率也较差。所有患者预后良好，无疾病生存。
青少年腮腺肿瘤少见，但具有与成人不同的特征。由于青少年患者需要长期随访，良性多形性腺瘤有复发倾向，恶性肿瘤尤其是中低级别恶性肿瘤预后较差，更可能观察到不良事件。
