Skrypuch O W, Willis N R
Can J Ophthalmol. 1987 Apr;22(3):181-5.
The clinical and pathological corneal findings in a patient with lattice dystrophy of the cornea type I are presented. Amyloid, the corneal stromal deposit in this dystrophy, has been shown to be heterogeneous by means of immunohistochemical techniques despite uniform ultrastructural features. The possible sources of amyloid include leakage from serum, extracellular breakdown of corneal collagen and, most probably, localized intracellular production.
本文介绍了一名患有I型角膜格子状营养不良患者的临床和病理角膜检查结果。尽管淀粉样蛋白在超微结构特征上较为一致,但通过免疫组织化学技术已表明,作为这种营养不良中角膜基质沉积物的淀粉样蛋白具有异质性。淀粉样蛋白的可能来源包括血清渗漏、角膜胶原的细胞外分解,以及最有可能的局部细胞内产生。