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肝移植逆转乙型肝炎相关性失代偿期肝硬化肝性脊髓病:病例报告及文献复习。

Liver Transplantation Reverses Hepatic Myelopathy in Hepatitis B-Related Decompensated Liver Cirrhosis: Case Report and Review of the Literature.

机构信息

Department of Organ Transplantation Center, The First Affiliated Hospital of University of Science and Technology of China, Hefei, Anhui, China.

Department of Organ Transplantation Center, The First Affiliated Hospital of University of Science and Technology of China, Hefei, Anhui, China.

出版信息

Transplant Proc. 2022 Jan-Feb;54(1):158-160. doi: 10.1016/j.transproceed.2021.11.016. Epub 2021 Dec 24.

DOI:10.1016/j.transproceed.2021.11.016
PMID:34961599
Abstract

Severe neurologic complications after chronic liver disease greatly affect the patient's quality of life. Hepatic myelopathy (HM) is a rare but devastating disease, in chronic liver disease. The limbs of patients with HM show slowly progressive symmetrical spastic paralysis without sensory loss. Management of this severe neurologic complication is challenging. These patients often require timely and effective clinical intervention. Although liver transplantation is one of the effective treatments for HM, the prognosis of these patients remains poor, many of them spend their lives in wheelchairs. Here, we report a patient with HM after hepatitis B virus related decompensated liver cirrhosis who recovered well after liver transplant. This work was carried out in compliance with the Helsinki Congress and the Declaration of Istanbul.

摘要

慢性肝脏疾病后出现严重的神经系统并发症极大地影响了患者的生活质量。肝性脊髓病(HM)是一种罕见但具有破坏性的疾病,在慢性肝脏疾病中。HM 患者的四肢表现为进行性缓慢对称痉挛性瘫痪,无感觉丧失。管理这种严重的神经系统并发症具有挑战性。这些患者通常需要及时有效的临床干预。虽然肝移植是 HM 的有效治疗方法之一,但这些患者的预后仍然较差,许多患者终身坐在轮椅上。在这里,我们报告了一例乙型肝炎病毒相关失代偿性肝硬化后发生 HM 的患者,肝移植后恢复良好。这项工作符合赫尔辛基大会和伊斯坦布尔宣言的规定。

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Liver Transplantation Reverses Hepatic Myelopathy in Hepatitis B-Related Decompensated Liver Cirrhosis: Case Report and Review of the Literature.肝移植逆转乙型肝炎相关性失代偿期肝硬化肝性脊髓病:病例报告及文献复习。
Transplant Proc. 2022 Jan-Feb;54(1):158-160. doi: 10.1016/j.transproceed.2021.11.016. Epub 2021 Dec 24.
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引用本文的文献

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Am J Transl Res. 2024 Sep 15;16(9):4867-4875. doi: 10.62347/QQEI5676. eCollection 2024.
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Liver Transplantation Reverses Hepatic Myelopathy in the Decompensated Phase of Cirrhosis: Case Report and Literature Review.肝移植逆转肝硬化失代偿期的肝性脊髓病:病例报告及文献综述
J Clin Transl Hepatol. 2024 Apr 28;12(4):436-442. doi: 10.14218/JCTH.2023.00487. Epub 2024 Mar 13.
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Spontaneous remission of hepatic myelopathy in a patient with alcoholic cirrhosis: A case report.
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World J Clin Cases. 2022 Oct 26;10(30):11172-11177. doi: 10.12998/wjcc.v10.i30.11172.
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Therapeutic effect of autologous bone marrow cells injected into the liver under the guidance of B‑ultrasound in the treatment of HBV‑related decompensated liver cirrhosis.B超引导下自体骨髓细胞注入肝脏治疗HBV相关失代偿期肝硬化的疗效
Exp Ther Med. 2022 Aug 22;24(4):633. doi: 10.3892/etm.2022.11570. eCollection 2022 Oct.