Bencharef Hanaa, Koudouss Asmaa, Jaddaoui Samiha, Dassouli Dounia, Madani Abdellah, Qachouh Meryem, Oukkache Bouchra
Laboratoire d'hématologie, Centre hospitalier universitaire IBN Rochd, Casablanca, Maroc, Université Hassan II, faculté de médecine et de pharmacie, Casablanca, Maroc.
Service d'hématologie-oncologie pédiatrique, Hôpital 20 Aout 1953, Casablanca, Maroc, Université Hassan II, faculté de médecine et de pharmacie, Casablanca, Maroc.
Ann Biol Clin (Paris). 2021 Dec 1;79(6):597-602. doi: 10.1684/abc.2021.1684.
Large granular lymphocyte leukemia (LGL) constitutes a heterogeneous entity with very different immunophenotypic, clonal and evolutionary characteristics. The most common LGL-T are CD3 +, CD8 +, CD16 +, CD57 +, CD56-. The majority of patients have a chronic disease, systemic signs are rare, and symptoms mainly result from neutropenia or associated autoimmune diseases. We report here a very special case of a 44-year-old woman patient diagnosed with aggressive LGL-T variant also expressing CD56.
大颗粒淋巴细胞白血病（LGL）是一种具有非常不同的免疫表型、克隆和进化特征的异质性疾病实体。最常见的LGL-T细胞是CD3 +、CD8 +、CD16 +、CD57 +、CD56-。大多数患者患有慢性病，全身症状罕见，症状主要由中性粒细胞减少或相关自身免疫性疾病引起。我们在此报告一例非常特殊的病例，一名44岁女性患者被诊断为侵袭性LGL-T变异型，同时也表达CD56。
