Chen Yan-Li, Zheng Li-Qiang, Li Tie-Jun, Sun Zhao-Qing, Hao Ying, Wu Bao-Gang, Sun Ying-Xian
Department of Cardiology, The First Hospital of China Medical University, Shenyang, Liaoning, China.
Department of Clinical Epidemiology, Library, Shengjing Hospital of China Medical University, Shenyang, Liaoning, China.
Int J Hypertens. 2021 Dec 18;2021:1061800. doi: 10.1155/2021/1061800. eCollection 2021.
This study aimed to investigate the relationship between kinesin-like family 6 (KIF6) polymorphisms and hypertension in a northeast Chinese cohort. In this study, two single nucleotide polymorphisms of KIF6 (rs20456 and rs6930913) and their haplotype were analyzed in 382 hypertension patients and 378 controls with SHEsis analysis platform, and the gene-environmental interactions were evaluated with logistic regression analysis. After adjusting for confounding factors, significantly lower risk of hypertension was observed in participants with genotype TC (0.416 (CI 0.299-0.578), < 0.001) and CC (0.577 (0.389-0.857), =0.007) of rs20456 compared with TT. For rs6930913, allele T (0.522 (0.386-0.704), < 0.001), genotype TT (0.325 (0.205-0.515), < 0.001), and genotype CT (0.513 (0.379-0.693), < 0.001) were significantly associated with lower risk of hypertension than allele C and CC genotype, respectively. Gene-environment analyses confirmed the significant influence on hypertension by the interactions between genotypes distribution in rs20456 (CT: =0.036, TT: =0.022) and smoking status. No interactions were found between smoking and rs6930913, except those with dominant or recessive genetic models (both =0.006). There were no interactions between KIF6 and overweight (all > 0.05). Haplotype analyses showed that CC (=0.005) and TC (=0.001) of rs20456 and rs6930913 were significantly associated with a statistically increased risk of hypertension. The false-positive report probability (FPRP) analysis was used to verify significant findings. In conclusions, KIF6 might affect the susceptibility of hypertension. The allele C (rs20456) and allele T (rs690913) were inclined to protect individuals from hypertension both in genotype and haplotype analyses.
本研究旨在调查中国东北人群中驱动蛋白样家族6（KIF6）基因多态性与高血压之间的关系。本研究采用SHEsis分析平台，对382例高血压患者和378例对照者的KIF6基因的两个单核苷酸多态性（rs20456和rs6930913）及其单倍型进行分析，并通过逻辑回归分析评估基因-环境相互作用。在调整混杂因素后，rs20456基因型为TC（0.416（95%置信区间0.299 - 0.578），P < 0.001）和CC（0.577（0.389 - 0.857），P = 0.007）的参与者患高血压的风险显著低于TT基因型。对于rs6930913，等位基因T（0.522（0.386 - 0.704），P < 0.001）、基因型TT（0.325（0.205 - 0.515），P < 0.001）和基因型CT（0.513（0.379 - 0.693），P < 0.001）与较低的高血压风险显著相关，分别低于等位基因C和CC基因型。基因-环境分析证实，rs20456基因型分布（CT：P = 0.036，TT：P = 0.022）与吸烟状态之间的相互作用对高血压有显著影响。除显性或隐性遗传模型外（均P = 0.006），未发现吸烟与rs6930913之间存在相互作用。KIF6与超重之间未发现相互作用（所有P > 0.05）。单倍型分析显示，rs20456和rs6930913的CC（P = 0.005）和TC（P = 0.001）单倍型与高血压风险显著增加相关。采用假阳性报告概率（FPRP）分析来验证显著结果。总之，KIF6可能影响高血压易感性。在基因型和单倍型分析中，等位基因C（rs20456）和等位基因T（rs690913）均倾向于保护个体免受高血压影响。
