Ma Rang-Gui, Xia Zhi, Shang Hua-Yu
School of Sports Medicine and Health, Chengdu Sport University, Chengdu 610041, China.
College of Physical Education and Health, Wenzhou University, Wenzhou 325035, China.
Sheng Li Xue Bao. 2021 Dec 25;73(6):1025-1034.
Cells selectively scavenge redundant or damaged mitochondria by mitophagy, which is an important mechanism of mitochondrial quality control. Recent studies have shown that mitophagy is mainly regulated by autophagy-related genes (Atgs) in yeast cells, while mitochondrial membrane associated proteins such as PTEN-induced putative kinase 1 (PINK1), NIX/BNIP3L, BNIP3, FUN14 domain containing 1 (FUNDC1), FKBP8/FKBP38, Bcl-2-like protein 13 (Bcl2L13), nucleotide binding domain and leucine-rich-repeat-containing proteins X1 (NLRX1), prohibitin 2 (PHB2) and lipids such as cardiolipin (CL) are the key mitophagic receptors in mammalian cells, which can selectively recognize damaged mitochondria, recruit them into isolation membranes by binding to microtubule-associated protein 1 light chain 3 (LC3) or γ-aminobutyric acid receptor-associated protein (GABARAP), and then fuse with lysosomes to eliminate the trapped mitochondria. This article reviews recent research progress of mitophagy-related receptor proteins.
细胞通过线粒体自噬选择性清除多余或受损的线粒体，这是线粒体质量控制的重要机制。最近的研究表明，线粒体自噬在酵母细胞中主要受自噬相关基因（Atgs）调控，而在哺乳动物细胞中，线粒体膜相关蛋白如PTEN诱导的假定激酶1（PINK1）、NIX/BNIP3L、BNIP3、含FUN14结构域蛋白1（FUNDC1）、FKBP8/FKBP38、Bcl-2样蛋白13（Bcl2L13）、核苷酸结合结构域富含亮氨酸重复序列蛋白X1（NLRX1）、抑制素2（PHB2）以及心磷脂（CL）等脂质是关键的线粒体自噬受体，它们可选择性识别受损线粒体，通过与微管相关蛋白1轻链3（LC3）或γ-氨基丁酸受体相关蛋白（GABARAP）结合将其招募到隔离膜中，然后与溶酶体融合以清除捕获的线粒体。本文综述了线粒体自噬相关受体蛋白的最新研究进展。
