Department of Neurology, The First Affiliated Hospital, Sun Yat-Sen University, Guangdong Provincial Key Laboratory for Diagnosis and Treatment of Major Neurological Diseases, National Key Clinical Department and Key Discipline of Neurology, Guangzhou, China.
Department of Medical Imaging, Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in Southern China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China.
Eur J Neurol. 2022 Apr;29(4):1035-1043. doi: 10.1111/ene.15233. Epub 2022 Jan 6.
Accumulating evidence indicates that dynamic amplitude of low-frequency fluctuations (dALFF) or dynamic functional connectivity (dFC) can provide complementary information, distinct from static amplitude of low-frequency fluctuations (sALFF) or static functional connectivity (sFC), in detecting brain functional abnormalities in brain diseases. We aimed to examine whether dALFF and dFC can offer valuable information for the detection of functional brain abnormalities in patients with blepharospasm.
We collected resting-state functional magnetic resonance imaging data from 46 patients each of blepharospasm, hemifacial spasm (HFS), and healthy controls (HCs). We examined intergroup differences in sALFF and dALFF to investigate abnormal regional brain activity in patients with blepharospasm. Based on the dALFF results, we conducted seed-based sFC and dFC analyses to identify static and dynamic connectivity changes in brain networks centered on areas showing abnormal temporal variability of local brain activity in patients with blepharospasm.
Compared with HCs, patients with blepharospasm displayed different brain functional change patterns characterized by increased sALFF in the left primary motor cortex (PMC) but increased dALFF variance in the right PMC. However, differences were not found between patients with HFS and HCs. Additionally, patients with blepharospasm exhibited decreased dFC strength, but no change in sFC, between right PMC and ipsilateral cerebellum compared with HCs; these findings were replicated when patients with blepharospasm were compared to those with HFS.
Our findings highlight that dALFF and dFC are complementary to sALFF and sFC and can provide valuable information for detecting brain functional abnormalities in blepharospasm. Blepharospasm may be a network disorder involving the cortico-ponto-cerebello-thalamo-cortical circuit.
越来越多的证据表明，低频波动的动态幅度（dALFF）或动态功能连接（dFC）可以提供与低频波动的静态幅度（sALFF）或静态功能连接（sFC）不同的补充信息，用于检测脑部疾病中的脑功能异常。我们旨在研究 dALFF 和 dFC 是否可以为检测眼睑痉挛患者的功能性脑异常提供有价值的信息。
我们收集了 46 例眼睑痉挛、面肌痉挛（HFS）和健康对照者（HC）的静息态功能磁共振成像数据。我们检查了 sALFF 和 dALFF 的组间差异，以研究眼睑痉挛患者的区域性脑活动异常。基于 dALFF 结果，我们进行了基于种子的 sFC 和 dFC 分析，以确定以显示眼睑痉挛患者局部脑活动时间变异性异常的区域为中心的脑网络中的静态和动态连接变化。
与 HCs 相比，眼睑痉挛患者表现出不同的脑功能变化模式，表现为左侧初级运动皮层（PMC）的 sALFF 增加，但右侧 PMC 的 dALFF 方差增加。然而，在 HFS 患者和 HCs 之间未发现差异。此外，与 HCs 相比，眼睑痉挛患者的右侧 PMC 与同侧小脑之间的 dFC 强度降低，但 sFC 无变化；当将眼睑痉挛患者与 HFS 患者进行比较时，也发现了这些发现。
我们的研究结果强调了 dALFF 和 dFC 是 sALFF 和 sFC 的补充，可以为检测眼睑痉挛患者的脑功能异常提供有价值的信息。眼睑痉挛可能是一种涉及皮质-桥脑-小脑-丘脑-皮质回路的网络障碍。
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